MetaCyc Pathway: L-glutamate and L-glutamine biosynthesis in Sinorhizobium meliloti 1021

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Reactions and Genes L-Glutamine (C)
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Glutamate dehydrogenase (NAD(P)(+)) (in reverse):
2-oxoglutarate + ammonium + NAD(P)H + H+→L-glutamate + NAD(P)+ + H2O (EC 1.4.1.3)
No genes
Glutamate synthase (ferredoxin) (in reverse):
2-oxoglutarate + L-glutamine + 2 H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→2 L-glutamate + 2 an oxidized ferredoxin [iron-sulfur] cluster (EC 1.4.7.1)
No genes
Glutamate synthase (NADH) (in reverse):
2-oxoglutarate + L-glutamine + NADH + H+→2 L-glutamate + NAD+ (EC 1.4.1.14)
SMc01814 -0.1
SMc04026 +0.9
Glutamate synthase (NADPH):
L-glutamine + H2O→L-glutamate + ammonia + H+ (EC 1.4.1.13; 1.4.1.14; 1.4.7.1; 2.6.1.85; 3.5.1.2; 3.5.1.38; 4.1.3.27; 4.3.2.10; 4.3.3.6; 6.3.4.2; 6.3.5.13; 6.3.5.2; 6.3.5.4; 6.3.5.5; 6.3.5.6; 6.3.5.7)
SM_b20481 +0.0
SM_b20528 +0.3
SM_b20652 -0.0
SM_b21227 -0.1
SMa1377 +0.1
SMc00394 N.D.
SMc00486 -5.5
SMc01025 N.D.
SMc01215 -4.9
SMc01350 N.D.
SMc01352 N.D.
SMc01353 N.D.
SMc01569 -4.9
SMc01814 -0.1
SMc02611 -0.6
SMc02612 +0.1
SMc02725 -7.6
SMc02847 +0.0
SMc02881 -0.1
SMc03236 -0.1
SMc03245 +0.2
SMc03943 -0.1
SMc04013 +0.1
SMc04026 +0.9
SMc04028 +0.7
Glutamate--ammonia ligase:
L-glutamate + ammonium + ATP→L-glutamine + ADP + H+ + phosphate (EC 6.3.1.2)
SM_b20745 +0.1
SMc00762 -0.1
SMc00948 -0.5
SMc01594 -0.0
SMc01973 -0.0
SMc02352 -0.1
SMc02613 +0.1
Glutamate dehydrogenase (NADP(+)) (in reverse):
2-oxoglutarate + ammonium + NADPH + H+→L-glutamate + NADP+ + H2O (EC 1.4.1.4)
SMa0228 -0.0
Glutamate synthase (NADPH) (in reverse):
2-oxoglutarate + ammonia + NADPH + 2 H+→L-glutamate + NADP+ + H2O (EC 1.4.1.13; 1.4.1.14)
SM_b20528 +0.3
SMc01814 -0.1
SMc02611 -0.6
SMc02612 +0.1
SMc02847 +0.0
SMc04026 +0.9
SMc04028 +0.7

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information