MetaCyc Pathway: superpathway of L-threonine biosynthesis in Sinorhizobium meliloti 1021

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Reactions and Genes L-Lysine (C)
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Aspartate transaminase (in reverse):
oxaloacetate + L-glutamate→L-aspartate + 2-oxoglutarate (EC 2.6.1.1)
SM_b20039 -0.0
SMa0387 +0.0
SMa1495 -0.1
SMc00294 -1.4
SMc00490 +0.1
SMc01406 +0.1
SMc01578 -0.2
SMc01969 -0.0
SMc02251 +0.1
SMc02262 +0.1
SMc02393 -0.0
SMc04326 +0.0
SMc04386 -3.9
Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP (EC 2.7.2.4)
SMc02438 N.D.
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate (EC 1.2.1.11)
SMc04410 N.D.
Homoserine dehydrogenase (in reverse):
L-aspartate 4-semialdehyde + NAD(P)H + H+→L-homoserine + NAD(P)+ (EC 1.1.1.3)
SMc00293 -7.0
Homoserine kinase:
L-homoserine + ATP→O-phospho-L-homoserine + ADP + H+ (EC 2.7.1.39)
SMa1760 -0.2
SMc00017 -4.4
Threonine synthase:
O-phospho-L-homoserine + H2O→L-threonine + phosphate (EC 4.2.3.1)
SMa0485 +0.2
SMc00077 N.D.

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information