MetaCyc Pathway: 2-methyl-branched fatty acid β-oxidation in Sinorhizobium meliloti 1021

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Reactions and Genes L-Lysine (C)
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Butyrate--CoA ligase:
a short-chain 2-methyl-branched fatty acid + ATP + coenzyme A→a short-chain 2-methyl fatty acyl-CoA + AMP + diphosphate (EC 6.2.1.2)
No genes
a long-chain 2-methyl fatty acyl-CoA + an oxidized electron-transfer flavoprotein + H+→a long-chain (2E)-2-methyl-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.8)
No genes
Butyrate--CoA ligase:
a medium-chain 2-methyl-branched fatty acid + ATP + coenzyme A→a medium-chain 2-methyl fatty acyl-CoA + AMP + diphosphate (EC 6.2.1.2)
No genes
a short-chain 2-methyl fatty acyl-CoA + an oxidized electron-transfer flavoprotein + H+→a short-chain (2E)-2-methyl-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.5)
No genes
a medium-chain 2-methyl fatty acyl-CoA + an oxidized electron-transfer flavoprotein + H+→a medium-chain (2E)-2-methyl-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.7)
SMc00977 +0.1
SMc01359 N.D.
SMc02229 -3.3
Enoyl-CoA hydratase (in reverse):
a long-chain (2E)-2-methyl-2-enoyl-CoA + H2O→a long-chain (3S)-3-hydroxy-2-methylacyl-CoA (EC 4.2.1.17)
SM_b20752 +0.1
SM_b21632 -0.0
SM_b21633 -0.1
SMa1408 -0.2
SMc00976 -0.1
SMc01153 -0.8
SMc01638 +0.2
SMc01641 +0.3
SMc01669 +0.0
SMc01806 -0.1
SMc02227 -4.7
SMc04398 N.D.
Enoyl-CoA hydratase (in reverse):
a short-chain (2E)-2-methyl-2-enoyl-CoA + H2O→a short-chain (3S)-3-hydroxy-2-methylacyl-CoA (EC 4.2.1.17)
SM_b20752 +0.1
SM_b21632 -0.0
SM_b21633 -0.1
SMa1408 -0.2
SMc00976 -0.1
SMc01153 -0.8
SMc01638 +0.2
SMc01641 +0.3
SMc01669 +0.0
SMc01806 -0.1
SMc02227 -4.7
SMc04398 N.D.
Enoyl-CoA hydratase (in reverse):
a medium-chain (2E)-2-methyl-2-enoyl-CoA + H2O→a medium-chain (3S)-3-hydroxy-2-methylacyl-CoA (EC 4.2.1.17)
SM_b20752 +0.1
SM_b21632 -0.0
SM_b21633 -0.1
SMa1408 -0.2
SMc00976 -0.1
SMc01153 -0.8
SMc01638 +0.2
SMc01641 +0.3
SMc01669 +0.0
SMc01806 -0.1
SMc02227 -4.7
SMc04398 N.D.
3-hydroxyacyl-CoA dehydrogenase:
a long-chain (3S)-3-hydroxy-2-methylacyl-CoA + NAD+→a long-chain 2-methyl-3-oxoacyl-CoA + NADH + H+ (EC 1.1.1.35)
SM_b21632 -0.0
SMc01638 +0.2
SMc02227 -4.7
3-hydroxy-2-methylbutyryl-CoA dehydrogenase:
a short-chain (3S)-3-hydroxy-2-methylacyl-CoA + NAD+→a short-chain 2-methyl-3-oxoacyl-CoA + NADH + H+ (EC 1.1.1.178)
No genes
3-hydroxyacyl-CoA dehydrogenase:
a medium-chain (3S)-3-hydroxy-2-methylacyl-CoA + NAD+→a medium-chain 2-methyl-3-oxoacyl-CoA + NADH + H+ (EC 1.1.1.35)
SM_b21632 -0.0
SMc01638 +0.2
SMc02227 -4.7
Acetyl-CoA C-acyltransferase (in reverse):
a long-chain 2-methyl-3-oxoacyl-CoA + coenzyme A→a long-chain 2-methyl fatty acyl-CoA + propanoyl-CoA (EC 2.3.1.16)
SM_b20589 +0.1
SMa1450 +0.1
SMc00262 -0.4
SMc00966 -0.0
SMc02228 -3.8
SMc03879 -5.0
Acetyl-CoA C-acyltransferase (in reverse):
a short-chain 2-methyl-3-oxoacyl-CoA + coenzyme A→a short-chain 2-methyl fatty acyl-CoA + propanoyl-CoA (EC 2.3.1.16)
SM_b20589 +0.1
SMa1450 +0.1
SMc00262 -0.4
SMc00966 -0.0
SMc02228 -3.8
SMc03879 -5.0
Acetyl-CoA C-acyltransferase (in reverse):
a medium-chain 2-methyl-3-oxoacyl-CoA + coenzyme A→a medium-chain 2-methyl fatty acyl-CoA + propanoyl-CoA (EC 2.3.1.16)
SM_b20589 +0.1
SMa1450 +0.1
SMc00262 -0.4
SMc00966 -0.0
SMc02228 -3.8
SMc03879 -5.0

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information