MetaCyc Pathway: phenylacetate degradation I (aerobic) in Burkholderia phytofirmans PsJN

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Reactions and Genes L-Tryptophan (C)
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Phenylacetate--CoA ligase:
phenylacetate + ATP + coenzyme A→phenylacetyl-CoA + AMP + diphosphate (EC 6.2.1.30)
BPHYT_RS17360 -0.0
phenylacetyl-CoA + NADPH + dioxygen + H+→2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + NADP+ + H2O (EC 1.14.13.149)
BPHYT_RS18250 -0.4
BPHYT_RS18255 +0.3
2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA→2-oxepin-2(3H)-ylideneacetyl-CoA (EC 5.3.3.18)
BPHYT_RS17350 N.D.
2-oxepin-2(3H)-ylideneacetyl-CoA + H2O→3-oxo-5,6-didehydrosuberyl-CoA semialdehyde (EC 3.3.2.12)
BPHYT_RS06755 N.D.
3-oxo-5,6-didehydrosuberyl-CoA semialdehyde + NADP+ + H2O→3-oxo-5,6-didehydrosuberyl-CoA + NADPH + 2 H+ (EC 1.2.1.91)
BPHYT_RS17340 -0.1
3-oxo-5,6-didehydrosuberyl-CoA + coenzyme A→(2E)-5-carboxy-2-pentenoyl-CoA + acetyl-CoA (EC 2.3.1.223)
BPHYT_RS17345 -0.2
Enoyl-CoA hydratase (in reverse):
(2E)-5-carboxy-2-pentenoyl-CoA + H2O→(3S)-hydroxyadipyl-CoA (EC 4.2.1.17)
BPHYT_RS02345 -0.2
BPHYT_RS03225 +0.2
BPHYT_RS03235 +0.2
BPHYT_RS03825 N.D.
BPHYT_RS06755 N.D.
BPHYT_RS06760 +0.3
BPHYT_RS08375 N.D.
BPHYT_RS08630 +0.2
BPHYT_RS09560 +0.0
BPHYT_RS10815 N.D.
BPHYT_RS11780 N.D.
BPHYT_RS13345 -0.1
BPHYT_RS13545 -0.4
BPHYT_RS14830 +0.1
BPHYT_RS17335 -0.0
BPHYT_RS17350 N.D.
BPHYT_RS20025 -0.3
BPHYT_RS25360 N.D.
BPHYT_RS25695 N.D.
BPHYT_RS27105 +0.2
BPHYT_RS27895 -0.3
BPHYT_RS28015 -0.3
BPHYT_RS28020 N.D.
BPHYT_RS28620 +0.5
BPHYT_RS35465 -2.4
3-hydroxyacyl-CoA dehydrogenase:
(3S)-hydroxyadipyl-CoA + NAD+→3-oxoadipoyl-CoA + NADH + H+ (EC 1.1.1.35)
BPHYT_RS03225 +0.2
BPHYT_RS06760 +0.3
BPHYT_RS09560 +0.0
BPHYT_RS13545 -0.4
BPHYT_RS28020 N.D.
BPHYT_RS34155 +0.5
3-oxoadipyl-CoA thiolase (in reverse):
3-oxoadipoyl-CoA + coenzyme A→succinyl-CoA + acetyl-CoA (EC 2.3.1.174)
BPHYT_RS17345 -0.2
BPHYT_RS29385 -0.8

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information