MetaCyc Pathway: pyruvate fermentation to butanol I in Burkholderia phytofirmans PsJN

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Reactions and Genes L-Tryptophan (C)
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Pyruvate synthase:
pyruvate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster→acetyl-CoA + CO2 + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster (EC 1.2.7.1)
No genes
Acetyl-CoA C-acyltransferase:
2 acetyl-CoA→acetoacetyl-CoA + coenzyme A (EC 2.3.1.16; 2.3.1.9)
BPHYT_RS02230 +0.1
BPHYT_RS03230 +0.3
BPHYT_RS08275 +0.0
BPHYT_RS09150 -1.3
BPHYT_RS09180 -0.0
BPHYT_RS09565 +0.6
BPHYT_RS17345 -0.2
BPHYT_RS21955 -0.6
BPHYT_RS29385 -0.8
3-hydroxyacyl-CoA dehydrogenase (in reverse):
acetoacetyl-CoA + NADH + H+→(S)-3-hydroxybutanoyl-CoA + NAD+ (EC 1.1.1.35)
BPHYT_RS03225 +0.2
BPHYT_RS06760 +0.3
BPHYT_RS09560 +0.0
BPHYT_RS13545 -0.4
BPHYT_RS28020 N.D.
BPHYT_RS34155 +0.5
(S)-3-hydroxybutanoyl-CoA→crotonyl-CoA + H2O (EC 4.2.1.150)
BPHYT_RS02345 -0.2
BPHYT_RS03225 +0.2
BPHYT_RS03235 +0.2
BPHYT_RS03825 N.D.
BPHYT_RS08375 N.D.
BPHYT_RS08630 +0.2
BPHYT_RS09560 +0.0
BPHYT_RS10815 N.D.
BPHYT_RS11780 N.D.
BPHYT_RS13545 -0.4
BPHYT_RS14830 +0.1
BPHYT_RS25360 N.D.
BPHYT_RS25695 N.D.
BPHYT_RS27105 +0.2
BPHYT_RS27895 -0.3
BPHYT_RS28620 +0.5
BPHYT_RS35465 -2.4
crotonyl-CoA[cytosol] + 2 NADH[cytosol] + 2 an oxidized ferredoxin [iron-sulfur] cluster[cytosol]→butanoyl-CoA[cytosol] + 2 NAD+[cytosol] + 2 a reduced ferredoxin [iron-sulfur] cluster[cytosol] (EC 1.3.1.109)
No genes
Butanal dehydrogenase (in reverse):
butanoyl-CoA + NAD(P)H + H+→1-butanal + coenzyme A + NAD(P)+ (EC 1.2.1.57)
No genes
Alcohol dehydrogenase (NADP(+)) (in reverse):
1-butanal + NADPH + H+→butan-1-ol + NADP+ (EC 1.1.1.2)
BPHYT_RS07065 +0.1
1-butanal + NADH + H+→butan-1-ol + NAD+
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information