MetaCyc Pathway: superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation in Sinorhizobium meliloti 1021

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Reactions and Genes L-Histidine (C)
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Arginine decarboxylase:
L-arginine + H+→agmatine + CO2 (EC 4.1.1.19)
SMa0680 +0.0
SMa0682 +0.1
SMc02983 -0.2
Agmatinase:
agmatine + H2O→putrescine + urea (EC 3.5.3.11)
SMc01802 +0.2
SMc01967 +0.1
Putrescine aminotransferase:
putrescine + 2-oxoglutarate→4-aminobutanal + L-glutamate (EC 2.6.1.82)
No genes
Glutamate--putrescine ligase:
putrescine + ATP + L-glutamate→γ-glutamyl-L-putrescine + ADP + H+ + phosphate (EC 6.3.1.11)
No genes
Aminobutyraldehyde dehydrogenase:
4-aminobutanal + NAD+ + H2O→4-aminobutanoate + NADH + 2 H+ (EC 1.2.1.19)
SM_b21110 -0.2
SMa0220 +0.0
SMa0796 +0.1
SMa1844 +0.0
SMa1848 +0.1
SMa2213 -0.1
SMc01656 -0.1
SMc01971 +0.1
SMc02689 -1.3
SMc04397 -0.0
γ-glutamyl-L-putrescine + dioxygen + H2O→4-(γ-L-glutamylamino)butanal + ammonium + hydrogen peroxide (EC 1.4.3.M3)
SMc01972 -0.3
4-(γ-L-glutamylamino)butanal + NAD(P)+ + H2O→4-(γ-L-glutamylamino)butanoate + NAD(P)H + 2 H+ (EC 1.2.1.99)
No genes
Gamma-glutamyl-gamma-aminobutyrate hydrolase:
4-(γ-L-glutamylamino)butanoate + H2O→4-aminobutanoate + L-glutamate (EC 3.5.1.94)
SMc03943 +0.3
4-aminobutyrate transaminase:
4-aminobutanoate + 2-oxoglutarate→succinate semialdehyde + L-glutamate (EC 2.6.1.19)
SM_b20423 +0.1
SM_b21186 +0.1
SMc00677 +0.1
SMc02413 -0.0
Succinate-semialdehyde dehydrogenase:
succinate semialdehyde + NAD+ + H2O→succinate + NADH + 2 H+ (EC 1.2.1.24)
No genes
succinate semialdehyde + NADP+ + H2O→succinate + NADPH + 2 H+ (EC 1.2.1.79)
SM_b21185 +0.0
SMa0260 -0.0
SMa1848 +0.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information