MetaCyc Pathway: (2S)-ethylmalonyl-CoA biosynthesis in Burkholderia phytofirmans PsJN

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Reactions and Genes L-Phenylalanine (C)
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Acetyl-CoA C-acyltransferase:
2 acetyl-CoA→acetoacetyl-CoA + coenzyme A (EC 2.3.1.16; 2.3.1.9)
BPHYT_RS02230 +0.1
BPHYT_RS03230 -0.1
BPHYT_RS08275 -0.1
BPHYT_RS09150 -0.1
BPHYT_RS09180 -0.2
BPHYT_RS09565 +0.8
BPHYT_RS17345 -1.9
BPHYT_RS21955 +0.3
BPHYT_RS29385 -0.2
Acetoacetyl-CoA reductase (in reverse):
acetoacetyl-CoA + NADPH + H+→(3R)-3-hydroxybutanoyl-CoA + NADP+ (EC 1.1.1.36)
BPHYT_RS00860 -0.1
BPHYT_RS09155 -1.0
BPHYT_RS15135 +0.5
BPHYT_RS27640 -0.0
BPHYT_RS29090 -0.2
3-hydroxybutyryl-CoA dehydratase:
(3R)-3-hydroxybutanoyl-CoA→crotonyl-CoA + H2O (EC 4.2.1.55)
BPHYT_RS22375 +0.0
crotonyl-CoA + CO2 + NADPH→(2S)-ethylmalonyl-CoA + NADP+ (EC 1.3.1.85)
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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information