MetaCyc Pathway: valproate β-oxidation in Burkholderia phytofirmans PsJN

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Reactions and Genes L-Phenylalanine (C)
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Butyrate--CoA ligase:
valproate + ATP + coenzyme A→valproyl-CoA + AMP + diphosphate (EC 6.2.1.2)
No genes
valproyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E)-2-propylpent-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.5)
No genes
Enoyl-CoA hydratase (in reverse):
(2E)-2-propylpent-2-enoyl-CoA + H2O→(3S)-3-hydroxy-2-propylpentanoyl-CoA (EC 4.2.1.17)
BPHYT_RS02345 -0.1
BPHYT_RS03225 -0.0
BPHYT_RS03235 +0.3
BPHYT_RS03825 N.D.
BPHYT_RS06755 N.D.
BPHYT_RS06760 -1.3
BPHYT_RS08375 N.D.
BPHYT_RS08630 -0.0
BPHYT_RS09560 -0.2
BPHYT_RS10815 N.D.
BPHYT_RS11780 N.D.
BPHYT_RS13345 -0.2
BPHYT_RS13545 -2.1
BPHYT_RS14830 +0.1
BPHYT_RS17335 -6.3
BPHYT_RS17350 N.D.
BPHYT_RS20025 -0.9
BPHYT_RS25360 N.D.
BPHYT_RS25695 N.D.
BPHYT_RS27105 +0.1
BPHYT_RS27895 -0.4
BPHYT_RS28015 -0.2
BPHYT_RS28020 N.D.
BPHYT_RS28620 -0.5
BPHYT_RS35465 -0.1
3-hydroxyacyl-CoA dehydrogenase:
(3S)-3-hydroxy-2-propylpentanoyl-CoA + NAD+→3-oxo-2-propylpentanoyl-CoA + NADH + H+ (EC 1.1.1.35)
BPHYT_RS03225 -0.0
BPHYT_RS06760 -1.3
BPHYT_RS09560 -0.2
BPHYT_RS13545 -2.1
BPHYT_RS34155 +0.5
Acetyl-CoA C-acyltransferase (in reverse):
3-oxo-2-propylpentanoyl-CoA + coenzyme A→pentanoyl-CoA + propanoyl-CoA (EC 2.3.1.16)
BPHYT_RS02230 +0.1
BPHYT_RS03230 -0.1
BPHYT_RS08275 -0.1
BPHYT_RS09150 -0.1
BPHYT_RS09180 -0.2
BPHYT_RS09565 +0.8
BPHYT_RS17345 -1.9
BPHYT_RS21955 +0.3
BPHYT_RS29385 -0.2
pentanoyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E)-pent-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.1)
BPHYT_RS23260 -0.1
BPHYT_RS25025 +0.1
(2E)-pent-2-enoyl-CoA + H2O→(3S)-3-hydroxypentanoyl-CoA
No genes
3-hydroxyacyl-CoA dehydrogenase:
(3S)-3-hydroxypentanoyl-CoA + NAD+→3-oxopentanoyl-CoA + NADH + H+ (EC 1.1.1.35)
BPHYT_RS03225 -0.0
BPHYT_RS06760 -1.3
BPHYT_RS09560 -0.2
BPHYT_RS13545 -2.1
BPHYT_RS34155 +0.5
Acetyl-CoA C-acyltransferase (in reverse):
3-oxopentanoyl-CoA + coenzyme A→propanoyl-CoA + acetyl-CoA (EC 2.3.1.16; 2.3.1.9)
BPHYT_RS02230 +0.1
BPHYT_RS03230 -0.1
BPHYT_RS08275 -0.1
BPHYT_RS09150 -0.1
BPHYT_RS09180 -0.2
BPHYT_RS09565 +0.8
BPHYT_RS17345 -1.9
BPHYT_RS21955 +0.3
BPHYT_RS29385 -0.2

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information