MetaCyc Pathway: ceramide and sphingolipid recycling and degradation (yeast) in Burkholderia phytofirmans PsJN

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Reactions and Genes L-Phenylalanine (C)
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(4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-[(1D-myo-inositol-1-O-yl)hydroxyphosphoryl]sphinganine + H2O→a very-long-chain (2'R)-2'-hydroxy-phytoceramide + 1D-myo-inositol 1-monophosphate + H+
No genes
(4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-{[6-O-(α-D-mannosyl)-1D-myo-inositol-1-O-yl]hydroxyphosphoryl}sphinganine + H2O→a very-long-chain (2'R)-2'-hydroxy-phytoceramide + phosphoinositol-α-mannoside + H+
No genes
(4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-[hydroxy(6-O-{6-O-[(1D-myo-inositol-1-O-yl)phosphoryl]-α-D-mannosyl}-1D-myo-inositol-1-O-yl)hydroxyphosphoryl]sphinganine + H2O→a very-long-chain (2'R)-2'-hydroxy-phytoceramide + phosphoinositol-α-mannoside-phosphoinositol
No genes
Ceramidase:
a dihydroceramide + H2O→sphinganine + a carboxylate (EC 3.5.1.23)
No genes
Ceramidase:
a very-long-chain (2'R)-2'-hydroxy-phytoceramide + H2O→a phytosphingosine + a very-long-chain (2R)-2-hydroxy fatty acid (EC 3.5.1.23)
No genes
Sphinganine kinase:
sphinganine + ATP→sphinganine 1-phosphate + ADP + H+ (EC 2.7.1.91)
No genes
sphinganine 1-phosphate + H2O→sphinganine + phosphate
No genes
Sphinganine kinase:
phytosphingosine + ATP→phytosphingosine (C18) 1-phosphate + ADP + H+ (EC 2.7.1.91)
No genes
Sphinganine-1-phosphate aldolase:
sphinganine 1-phosphate→hexadecanal + O-phosphoethanolamine (EC 4.1.2.27)
No genes
Sphinganine-1-phosphate aldolase:
phytosphingosine (C18) 1-phosphate→(R)-2-hydroxyhexadecanal + O-phosphoethanolamine (EC 4.1.2.27)
No genes
Aldehyde dehydrogenase (NAD(+)):
hexadecanal + NAD+ + H2O→palmitate + NADH + 2 H+ (EC 1.2.1.3)
BPHYT_RS00120 -0.1
BPHYT_RS00395 -0.1
BPHYT_RS05370 +0.4
BPHYT_RS07490 -0.4
BPHYT_RS09900 +0.2
BPHYT_RS17340 -6.3
BPHYT_RS18745 +0.1
BPHYT_RS19710 -0.1
BPHYT_RS20795 +0.3
BPHYT_RS25705 +0.1
BPHYT_RS25810 -0.4
BPHYT_RS27405 -0.3
BPHYT_RS28770 +0.2
BPHYT_RS29875 +0.0
BPHYT_RS30510 +0.1
BPHYT_RS32650 +0.2
BPHYT_RS34980 -0.1
BPHYT_RS35600 +0.0
phytosphingosine (C18) 1-phosphate + H2O→phytosphingosine + phosphate
No genes
Aldehyde dehydrogenase (NAD(+)):
(R)-2-hydroxyhexadecanal + NAD+ + H2O→(R)-2-hydroxyhexadecanoate + NADH + 2 H+ (EC 1.2.1.3)
BPHYT_RS00120 -0.1
BPHYT_RS00395 -0.1
BPHYT_RS05370 +0.4
BPHYT_RS07490 -0.4
BPHYT_RS09900 +0.2
BPHYT_RS17340 -6.3
BPHYT_RS18745 +0.1
BPHYT_RS19710 -0.1
BPHYT_RS20795 +0.3
BPHYT_RS25705 +0.1
BPHYT_RS25810 -0.4
BPHYT_RS27405 -0.3
BPHYT_RS28770 +0.2
BPHYT_RS29875 +0.0
BPHYT_RS30510 +0.1
BPHYT_RS32650 +0.2
BPHYT_RS34980 -0.1
BPHYT_RS35600 +0.0
Long-chain-fatty-acid--CoA ligase:
palmitate + ATP + coenzyme A→palmitoyl-CoA + AMP + diphosphate (EC 6.2.1.3)
BPHYT_RS08270 +0.2
BPHYT_RS17295 +0.0
BPHYT_RS19375 -0.0
(R)-2-hydroxyhexadecanoate + dioxygen→pentadecanoate + CO2 + H2O (EC 1.14.18.12)
No genes
Long-chain-fatty-acid--CoA ligase:
pentadecanoate + ATP + coenzyme A→pentadecanoyl-CoA + AMP + diphosphate (EC 6.2.1.3)
BPHYT_RS08270 +0.2
BPHYT_RS17295 +0.0
BPHYT_RS19375 -0.0

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information