MetaCyc Pathway: superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation in Burkholderia phytofirmans PsJN

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Reactions and Genes L-Phenylalanine (C)
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Pyruvate synthase:
pyruvate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster→acetyl-CoA + CO2 + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster (EC 1.2.7.1)
No genes
Acetaldehyde dehydrogenase (acetylating) (in reverse):
acetyl-CoA + NADH + H+→acetaldehyde + coenzyme A + NAD+ (EC 1.2.1.10)
BPHYT_RS07245 N.D.
Acetyl-CoA C-acyltransferase:
2 acetyl-CoA→acetoacetyl-CoA + coenzyme A (EC 2.3.1.16; 2.3.1.9)
BPHYT_RS02230 +0.1
BPHYT_RS03230 -0.1
BPHYT_RS08275 -0.1
BPHYT_RS09150 -0.1
BPHYT_RS09180 -0.2
BPHYT_RS09565 +0.8
BPHYT_RS17345 -1.9
BPHYT_RS21955 +0.3
BPHYT_RS29385 -0.2
Phosphate acetyltransferase:
acetyl-CoA + phosphate→acetyl phosphate + coenzyme A (EC 2.3.1.8)
BPHYT_RS21700 -0.1
BPHYT_RS27695 +0.0
Acetate kinase (in reverse):
acetyl phosphate + ADP→acetate + ATP (EC 2.7.2.1; 2.7.2.15)
BPHYT_RS06125 -0.0
BPHYT_RS26200 -0.2
Alcohol dehydrogenase (in reverse):
acetaldehyde + NADH + H+→ethanol + NAD+ (EC 1.1.1.1)
BPHYT_RS00510 -0.2
BPHYT_RS16150 -0.1
BPHYT_RS20205 +0.0
BPHYT_RS24470 -0.1
BPHYT_RS25430 N.D.
BPHYT_RS27390 -0.4
BPHYT_RS28135 +0.1
BPHYT_RS30075 -0.7
BPHYT_RS31305 +0.0
BPHYT_RS31860 N.D.
3-hydroxyacyl-CoA dehydrogenase (in reverse):
acetoacetyl-CoA + NADH + H+→(S)-3-hydroxybutanoyl-CoA + NAD+ (EC 1.1.1.35)
BPHYT_RS03225 -0.0
BPHYT_RS06760 -1.3
BPHYT_RS09560 -0.2
BPHYT_RS13545 -2.1
BPHYT_RS28020 N.D.
BPHYT_RS34155 +0.5
Butyrate--acetoacetate CoA-transferase (in reverse):
acetate + acetoacetyl-CoA→acetyl-CoA + acetoacetate (EC 2.8.3.9)
BPHYT_RS07875 -0.1
BPHYT_RS20785 -0.0
(S)-3-hydroxybutanoyl-CoA→crotonyl-CoA + H2O (EC 4.2.1.150)
BPHYT_RS02345 -0.1
BPHYT_RS03225 -0.0
BPHYT_RS03235 +0.3
BPHYT_RS03825 N.D.
BPHYT_RS08375 N.D.
BPHYT_RS08630 -0.0
BPHYT_RS09560 -0.2
BPHYT_RS10815 N.D.
BPHYT_RS11780 N.D.
BPHYT_RS13545 -2.1
BPHYT_RS14830 +0.1
BPHYT_RS25360 N.D.
BPHYT_RS25695 N.D.
BPHYT_RS27105 +0.1
BPHYT_RS27895 -0.4
BPHYT_RS28620 -0.5
BPHYT_RS35465 -0.1
crotonyl-CoA[cytosol] + 2 NADH[cytosol] + 2 an oxidized ferredoxin [iron-sulfur] cluster[cytosol]→butanoyl-CoA[cytosol] + 2 NAD+[cytosol] + 2 a reduced ferredoxin [iron-sulfur] cluster[cytosol] (EC 1.3.1.109)
No genes
Butanal dehydrogenase (in reverse):
butanoyl-CoA + NAD(P)H + H+→1-butanal + coenzyme A + NAD(P)+ (EC 1.2.1.57)
No genes
Phosphate butyryltransferase:
butanoyl-CoA + phosphate→butanoyl phosphate + coenzyme A (EC 2.3.1.19)
No genes
Branched-chain-fatty-acid kinase (in reverse):
butanoyl phosphate + ADP→butanoate + ATP (EC 2.7.2.14; 2.7.2.7)
No genes
Alcohol dehydrogenase (NADP(+)) (in reverse):
1-butanal + NADPH + H+→butan-1-ol + NADP+ (EC 1.1.1.2)
BPHYT_RS07065 +0.1
1-butanal + NADH + H+→butan-1-ol + NAD+
No genes
Butyrate--acetoacetate CoA-transferase (in reverse):
acetoacetyl-CoA + butanoate→acetoacetate + butanoyl-CoA (EC 2.8.3.9)
No genes
Acetoacetate decarboxylase:
acetoacetate + H+→acetone + CO2 (EC 4.1.1.4)
BPHYT_RS07740 -0.0
BPHYT_RS11935 N.D.

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information