MetaCyc Pathway: noradrenaline and adrenaline degradation in Burkholderia phytofirmans PsJN

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Reactions and Genes L-Phenylalanine (C)
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Catechol O-methyltransferase:
(R)-noradrenaline + S-adenosyl-L-methionine→L-normetanephrine + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.6)
No genes
Monoamine oxidase:
(R)-noradrenaline + dioxygen + H2O→3,4-dihydroxyphenylglycolaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.4)
No genes
Phenylethanolamine N-methyltransferase:
(R)-noradrenaline + S-adenosyl-L-methionine→(R)-adrenaline + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.28)
No genes
Monoamine oxidase:
(R)-adrenaline + dioxygen + H2O→3,4-dihydroxyphenylglycolaldehyde + hydrogen peroxide + methylamine (EC 1.4.3.4)
No genes
Catechol O-methyltransferase:
(R)-adrenaline + S-adenosyl-L-methionine→metanephrine + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.6)
No genes
Monoamine oxidase:
L-normetanephrine + dioxygen + H2O→3-methoxy-4-hydroxyphenylglycolaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.4)
No genes
Alcohol dehydrogenase (in reverse):
3,4-dihydroxyphenylglycolaldehyde + NADH + H+→(R)-3,4-dihydroxyphenylglycol + NAD+ (EC 1.1.1.1)
BPHYT_RS00510 -0.2
BPHYT_RS16150 -0.1
BPHYT_RS20205 +0.0
BPHYT_RS24470 -0.1
BPHYT_RS25430 N.D.
BPHYT_RS27390 -0.4
BPHYT_RS28135 +0.1
BPHYT_RS30075 -0.7
BPHYT_RS31305 +0.0
BPHYT_RS31860 N.D.
Aldehyde dehydrogenase (NAD(+)):
3,4-dihydroxyphenylglycolaldehyde + NAD+ + H2O→3,4-dihydroxymandelate + NADH + 2 H+ (EC 1.2.1.3)
BPHYT_RS00120 -0.1
BPHYT_RS00395 -0.1
BPHYT_RS05370 +0.4
BPHYT_RS07490 -0.4
BPHYT_RS09900 +0.2
BPHYT_RS17340 -6.3
BPHYT_RS18745 +0.1
BPHYT_RS19710 -0.1
BPHYT_RS20795 +0.3
BPHYT_RS25705 +0.1
BPHYT_RS25810 -0.4
BPHYT_RS27405 -0.3
BPHYT_RS28770 +0.2
BPHYT_RS29875 +0.0
BPHYT_RS30510 +0.1
BPHYT_RS32650 +0.2
BPHYT_RS34980 -0.1
BPHYT_RS35600 +0.0
Monoamine oxidase:
metanephrine + dioxygen + H2O→3-methoxy-4-hydroxyphenylglycolaldehyde + hydrogen peroxide + methylamine (EC 1.4.3.4)
No genes
Catechol O-methyltransferase:
(R)-3,4-dihydroxyphenylglycol + S-adenosyl-L-methionine→3-methoxy-4-hydroxyphenylglycol + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.6)
No genes
Catechol O-methyltransferase:
3,4-dihydroxymandelate + S-adenosyl-L-methionine→vanillylmandelate + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.6)
No genes
Alcohol dehydrogenase:
3-methoxy-4-hydroxyphenylglycol + NAD+→3-methoxy-4-hydroxyphenylglycolaldehyde + NADH + H+ (EC 1.1.1.1)
BPHYT_RS00510 -0.2
BPHYT_RS16150 -0.1
BPHYT_RS20205 +0.0
BPHYT_RS24470 -0.1
BPHYT_RS25430 N.D.
BPHYT_RS27390 -0.4
BPHYT_RS28135 +0.1
BPHYT_RS30075 -0.7
BPHYT_RS31305 +0.0
BPHYT_RS31860 N.D.
Aldehyde dehydrogenase (NAD(+)):
3-methoxy-4-hydroxyphenylglycolaldehyde + NAD+ + H2O→vanillylmandelate + NADH + 2 H+ (EC 1.2.1.3)
BPHYT_RS00120 -0.1
BPHYT_RS00395 -0.1
BPHYT_RS05370 +0.4
BPHYT_RS07490 -0.4
BPHYT_RS09900 +0.2
BPHYT_RS17340 -6.3
BPHYT_RS18745 +0.1
BPHYT_RS19710 -0.1
BPHYT_RS20795 +0.3
BPHYT_RS25705 +0.1
BPHYT_RS25810 -0.4
BPHYT_RS27405 -0.3
BPHYT_RS28770 +0.2
BPHYT_RS29875 +0.0
BPHYT_RS30510 +0.1
BPHYT_RS32650 +0.2
BPHYT_RS34980 -0.1
BPHYT_RS35600 +0.0

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information