MetaCyc Pathway: rosmarinic acid biosynthesis I in Burkholderia phytofirmans PsJN

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Reactions and Genes L-Phenylalanine (C)
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Phenylalanine ammonia-lyase:
L-phenylalanine→trans-cinnamate + ammonium (EC 4.3.1.24; 4.3.1.25; 5.4.3.10)
No genes
Aspartate transaminase:
L-tyrosine + 2-oxoglutarate→3-(4-hydroxyphenyl)pyruvate + L-glutamate (EC 2.6.1.1; 2.6.1.27; 2.6.1.5; 2.6.1.57)
BPHYT_RS00155 +0.1
BPHYT_RS02830 -0.0
BPHYT_RS04100 N.D.
BPHYT_RS05430 -0.0
BPHYT_RS05975 -0.2
BPHYT_RS06770 -0.2
BPHYT_RS06900 -5.8
BPHYT_RS08040 +0.0
BPHYT_RS08950 -1.7
BPHYT_RS09580 -0.2
BPHYT_RS10265 -0.0
BPHYT_RS10440 -0.2
BPHYT_RS13065 +0.1
BPHYT_RS13450 -0.4
BPHYT_RS14905 -1.2
BPHYT_RS15405 +0.0
BPHYT_RS15820 +0.2
BPHYT_RS17705 -0.2
BPHYT_RS21060 -0.2
BPHYT_RS21560 +0.1
BPHYT_RS21610 -0.0
BPHYT_RS21730 +0.2
BPHYT_RS22065 -0.1
BPHYT_RS22425 -0.1
BPHYT_RS26535 -0.1
BPHYT_RS26755 -0.0
BPHYT_RS27000 -0.0
BPHYT_RS28370 +0.0
BPHYT_RS28685 +0.3
BPHYT_RS28695 +0.1
BPHYT_RS30590 -0.3
BPHYT_RS30680 +0.1
BPHYT_RS32285 -0.2
BPHYT_RS32640 -0.0
BPHYT_RS35285 -0.2
Hydroxyphenylpyruvate reductase (in reverse):
3-(4-hydroxyphenyl)pyruvate + NAD(P)H + H+→(R)-3-(4-hydroxyphenyl)lactate + NAD(P)+ (EC 1.1.1.237)
No genes
trans-cinnamate + dioxygen + a reduced [NADPH-hemoprotein reductase]→4-coumarate + an oxidized [NADPH-hemoprotein reductase] + H2O (EC 1.14.14.91)
No genes
4-coumarate--CoA ligase:
4-coumarate + ATP + coenzyme A→(E)-4-coumaroyl-CoA + AMP + diphosphate (EC 6.2.1.12)
No genes
(R)-3-(4-hydroxyphenyl)lactate + (E)-4-coumaroyl-CoA→4-coumaroyl-4'-hydroxyphenyllactate + coenzyme A
No genes
4-coumaroyl-4'-hydroxyphenyllactate + dioxygen + a reduced [NADPH-hemoprotein reductase]→caffeoyl-4'-hydroxyphenyllactate + an oxidized [NADPH-hemoprotein reductase] + H2O
No genes
4-coumaroyl-4'-hydroxyphenyllactate + dioxygen + a reduced [NADPH-hemoprotein reductase]→4-coumaroyl-3',4'-dihydroxyphenyllactate + an oxidized [NADPH-hemoprotein reductase] + H2O
No genes
caffeoyl-4'-hydroxyphenyllactate + dioxygen + a reduced [NADPH-hemoprotein reductase]→(R)-rosmarinate + an oxidized [NADPH-hemoprotein reductase] + H2O
No genes
4-coumaroyl-3',4'-dihydroxyphenyllactate + dioxygen + a reduced [NADPH-hemoprotein reductase]→(R)-rosmarinate + an oxidized [NADPH-hemoprotein reductase] + H2O
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information