MetaCyc Pathway: 3-phenylpropanoate degradation in Burkholderia phytofirmans PsJN

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Reactions and Genes L-Phenylalanine (C)
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3-phenylpropanoate + ATP + coenzyme A→3-phenylpropanoyl-CoA + AMP + diphosphate
No genes
3-phenylpropanoyl-CoA + an oxidized electron carrier→(E)-cinnamoyl-CoA + a reduced two electron carrier
No genes
Enoyl-CoA hydratase (in reverse):
(E)-cinnamoyl-CoA + H2O→(S)-3-hydroxy-3-phenylpropanoyl-CoA (EC 4.2.1.17)
BPHYT_RS02345 -0.1
BPHYT_RS03225 -0.0
BPHYT_RS03235 +0.3
BPHYT_RS03825 N.D.
BPHYT_RS06755 N.D.
BPHYT_RS06760 -1.3
BPHYT_RS08375 N.D.
BPHYT_RS08630 -0.0
BPHYT_RS09560 -0.2
BPHYT_RS10815 N.D.
BPHYT_RS11780 N.D.
BPHYT_RS13345 -0.2
BPHYT_RS13545 -2.1
BPHYT_RS14830 +0.1
BPHYT_RS17335 -6.3
BPHYT_RS17350 N.D.
BPHYT_RS20025 -0.9
BPHYT_RS25360 N.D.
BPHYT_RS25695 N.D.
BPHYT_RS27105 +0.1
BPHYT_RS27895 -0.4
BPHYT_RS28015 -0.2
BPHYT_RS28020 N.D.
BPHYT_RS28620 -0.5
BPHYT_RS35465 -0.1
3-hydroxyacyl-CoA dehydrogenase:
(S)-3-hydroxy-3-phenylpropanoyl-CoA + NAD+→3-oxo-3-phenylpropanoyl-CoA + NADH + H+ (EC 1.1.1.35)
BPHYT_RS03225 -0.0
BPHYT_RS06760 -1.3
BPHYT_RS09560 -0.2
BPHYT_RS13545 -2.1
BPHYT_RS34155 +0.5
Acetyl-CoA C-acyltransferase (in reverse):
3-oxo-3-phenylpropanoyl-CoA + coenzyme A→benzoyl-CoA + acetyl-CoA (EC 2.3.1.16)
BPHYT_RS02230 +0.1
BPHYT_RS03230 -0.1
BPHYT_RS08275 -0.1
BPHYT_RS09150 -0.1
BPHYT_RS09180 -0.2
BPHYT_RS09565 +0.8
BPHYT_RS17345 -1.9
BPHYT_RS21955 +0.3
BPHYT_RS29385 -0.2
Benzoyl-CoA 3-monooxygenase:
benzoyl-CoA + NADPH + dioxygen + H+→3-hydroxybenzoyl-CoA + NADP+ + H2O (EC 1.14.13.58)
No genes
3-hydroxybenzoyl-CoA + a reduced two electron carrier + dioxygen→gentisate + an oxidized electron carrier + coenzyme A + H+
No genes
Gentisate 1,2-dioxygenase:
gentisate + dioxygen→3-maleylpyruvate + H+ (EC 1.13.11.4)
No genes
Maleylpyruvate isomerase:
3-maleylpyruvate→3-fumarylpyruvate (EC 5.2.1.4)
BPHYT_RS02805 +0.1
3-fumarylpyruvate + H2O→fumarate + pyruvate + H+ (EC 3.7.1.20)
BPHYT_RS02800 +0.0

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information