MetaCyc Pathway: superpathway of L-lysine, L-threonine and L-methionine biosynthesis I in Burkholderia phytofirmans PsJN

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Reactions and Genes L-Glutamine (C)
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Aspartate transaminase (in reverse):
oxaloacetate + L-glutamate→L-aspartate + 2-oxoglutarate
(EC 2.6.1.1)
BPHYT_RS00155 -0.0
BPHYT_RS04100 N.D.
BPHYT_RS05430 -0.1
BPHYT_RS05975 -0.1
BPHYT_RS06770 -0.1
BPHYT_RS08040 +0.0
BPHYT_RS08950 -1.7
BPHYT_RS09580 +0.2
BPHYT_RS10265 -0.0
BPHYT_RS10440 +0.1
BPHYT_RS13065 +0.1
BPHYT_RS13450 +0.2
BPHYT_RS15405 +0.1
BPHYT_RS15820 +0.0
BPHYT_RS21060 -0.4
BPHYT_RS21560 -0.0
BPHYT_RS21610 -0.1
BPHYT_RS21730 -0.1
BPHYT_RS22065 +0.0
BPHYT_RS22425 +0.0
BPHYT_RS26535 -0.1
BPHYT_RS27000 -0.2
BPHYT_RS28370 -0.3
BPHYT_RS28685 +0.0
BPHYT_RS28695 +0.1
BPHYT_RS30590 -0.3
BPHYT_RS30680 -0.0
BPHYT_RS35285 -0.2
Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP
(EC 2.7.2.4)
BPHYT_RS12410 N.D.
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate
(EC 1.2.1.11)
BPHYT_RS33895 N.D.
L-aspartate 4-semialdehyde + pyruvate→(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H+ + H2O (EC 4.3.3.7)
BPHYT_RS07320 +0.1
BPHYT_RS12615 -0.9
BPHYT_RS29250 +0.3
BPHYT_RS30940 -0.3
Homoserine dehydrogenase (in reverse):
L-aspartate 4-semialdehyde + NAD(P)H + H+→L-homoserine + NAD(P)+
(EC 1.1.1.3)
BPHYT_RS08955 -6.1
Homoserine kinase:
L-homoserine + ATP→O-phospho-L-homoserine + ADP + H+
(EC 2.7.1.39)
BPHYT_RS33645 -5.6
Homoserine O-succinyltransferase:
L-homoserine + succinyl-CoA→O-succinyl-L-homoserine + coenzyme A
(EC 2.3.1.46)
No genes
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+→(S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)+ + H2O (EC 1.17.1.8)
BPHYT_RS16800 N.D.
Cystathionine gamma-synthase:
O-succinyl-L-homoserine + L-cysteine→L-cystathionine + H+ + succinate
(EC 2.5.1.48)
BPHYT_RS13720 -0.1
BPHYT_RS33835 -7.3
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase:
(S)-2,3,4,5-tetrahydrodipicolinate + succinyl-CoA + H2ON-succinyl-2-amino-6-ketopimelate + coenzyme A
(EC 2.3.1.117)
BPHYT_RS12190 N.D.
Threonine synthase:
O-phospho-L-homoserine + H2O→L-threonine + phosphate
(EC 4.2.3.1)
BPHYT_RS08960 -4.6
Cysteine-S-conjugate beta-lyase:
L-cystathionine + H2O→L-homocysteine + ammonium + pyruvate
(EC 4.4.1.13)
No genes
Succinyldiaminopimelate transaminase (in reverse):
N-succinyl-2-amino-6-ketopimelate + L-glutamateN-succinyl-L,L-2,6-diaminopimelate + 2-oxoglutarate
(EC 2.6.1.17)
BPHYT_RS07695 N.D.
BPHYT_RS12185 -0.1
BPHYT_RS14915 -5.2
BPHYT_RS15580 +0.3
5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase:
L-homocysteine + 5-methyltetrahydropteroyl tri-L-glutamate→L-methionine + tetrahydropteroyl tri-L-glutamate
(EC 2.1.1.14)
BPHYT_RS26655 -0.3
Methionine synthase:
L-homocysteine + a 5-methyltetrahydrofolate→L-methionine + a tetrahydrofolate
(EC 2.1.1.13)
BPHYT_RS02305 -1.9
BPHYT_RS02310 -1.9
Succinyl-diaminopimelate desuccinylase:
N-succinyl-L,L-2,6-diaminopimelate + H2O→L,L-diaminopimelate + succinate
(EC 3.5.1.18)
BPHYT_RS12200 N.D.
Diaminopimelate epimerase:
L,L-diaminopimelate→meso-diaminopimelate
(EC 5.1.1.7)
BPHYT_RS01665 N.D.
BPHYT_RS05020 -0.2
BPHYT_RS24370 -0.4
BPHYT_RS35135 -0.0
Diaminopimelate decarboxylase:
meso-diaminopimelate + H+→L-lysine + CO2
(EC 4.1.1.20)
BPHYT_RS00645 +0.1
BPHYT_RS17930 -0.1
BPHYT_RS35090 +0.3

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information