MetaCyc Pathway: superpathway of L-phenylalanine biosynthesis in Pseudomonas fluorescens FW300-N2E2

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Reactions and Genes m-Inositol (C)
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3-deoxy-7-phosphoheptulonate synthase:
D-erythrose 4-phosphate + phosphoenolpyruvate + H2O→3-deoxy-D-arabino-heptulosonate 7-phosphate + phosphate (EC 2.5.1.54)
Pf6N2E2_2025 +0.1
Pf6N2E2_2453 +0.1
Pf6N2E2_2470 +1.6
3-dehydroquinate synthase:
3-deoxy-D-arabino-heptulosonate 7-phosphate→3-dehydroquinate + phosphate (EC 4.2.3.4)
Pf6N2E2_1564 -0.2
Pf6N2E2_3754 N.D.
3-dehydroquinate dehydratase:
3-dehydroquinate→3-dehydroshikimate + H2O (EC 4.2.1.10)
Pf6N2E2_3048 N.D.
Pf6N2E2_3510 N.D.
Pf6N2E2_5062 +0.0
Shikimate dehydrogenase (in reverse):
3-dehydroshikimate + NADPH + H+→shikimate + NADP+ (EC 1.1.1.25)
Pf6N2E2_2233 -0.2
Pf6N2E2_4130 N.D.
Pf6N2E2_5061 +0.0
Shikimate kinase:
shikimate + ATP→shikimate 3-phosphate + ADP + H+ (EC 2.7.1.71)
Pf6N2E2_3755 N.D.
3-phosphoshikimate 1-carboxyvinyltransferase:
shikimate 3-phosphate + phosphoenolpyruvate→5-enolpyruvoyl-shikimate 3-phosphate + phosphate (EC 2.5.1.19)
Pf6N2E2_2518 +0.6
Chorismate synthase:
5-enolpyruvoyl-shikimate 3-phosphate→chorismate + phosphate (EC 4.2.3.5)
Pf6N2E2_5822 N.D.
Chorismate mutase:
chorismate→prephenate (EC 5.4.99.5)
Pf6N2E2_2520 N.D.
Pf6N2E2_3822 +0.0
Prephenate dehydratase:
prephenate + H+→3-phenyl-2-oxopropanoate + CO2 + H2O (EC 4.2.1.51)
Pf6N2E2_1300 -0.1
Pf6N2E2_2520 N.D.
Aspartate transaminase (in reverse):
3-phenyl-2-oxopropanoate + L-glutamate→L-phenylalanine + 2-oxoglutarate (EC 2.6.1.1; 2.6.1.27; 2.6.1.57)
Pf6N2E2_1496 +0.4
Pf6N2E2_2127 +0.2
Pf6N2E2_2446 +0.2
Pf6N2E2_2519 +0.7
Pf6N2E2_2632 -0.3
Pf6N2E2_3173 -0.1
Pf6N2E2_3251 +0.2
Pf6N2E2_4288 +0.1
Pf6N2E2_4386 +0.1
Pf6N2E2_462 +0.0
Pf6N2E2_50 -1.3
Pf6N2E2_5300 +0.7
Pf6N2E2_5813 +0.1
Pf6N2E2_5890 +0.0
Pf6N2E2_5891 N.D.
Pf6N2E2_5895 -0.1
Pf6N2E2_5989 +0.1
Pf6N2E2_637 +0.0
Pf6N2E2_684 +0.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information