MetaCyc Pathway: 4-hydroxybenzoate biosynthesis III (plants) in Pseudomonas fluorescens FW300-N2E2

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Reactions and Genes propionate (C)
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4-coumarate--CoA ligase:
4-coumarate + ATP + coenzyme A→(E)-4-coumaroyl-CoA + AMP + diphosphate (EC 6.2.1.12)
Pf6N2E2_744 -0.2
(E)-4-coumaroyl-CoA + H2O→3S-(4-hydroxyphenyl)-3-hydroxy-propanoyl-CoA (EC 4.1.2.61)
No genes
3-hydroxyacyl-CoA dehydrogenase:
3S-(4-hydroxyphenyl)-3-hydroxy-propanoyl-CoA + NAD+→3-(4-hydroxyphenyl)-3-oxo-propanoyl-CoA + NADH + H+ (EC 1.1.1.35)
Pf6N2E2_1833 -0.0
Pf6N2E2_1850 +0.1
Pf6N2E2_1922 +0.1
Pf6N2E2_2290 N.D.
Pf6N2E2_3894 -0.0
Pf6N2E2_4690 -0.4
Pf6N2E2_6000 +0.0
Acetyl-CoA C-acyltransferase (in reverse):
3-(4-hydroxyphenyl)-3-oxo-propanoyl-CoA + coenzyme A→4-hydroxybenzoyl-CoA + acetyl-CoA (EC 2.3.1.16)
Pf6N2E2_1145 N.D.
Pf6N2E2_1675 +0.0
Pf6N2E2_1836 -0.5
Pf6N2E2_1851 +0.3
Pf6N2E2_2113 -0.1
Pf6N2E2_2289 N.D.
Pf6N2E2_2539 +0.2
Pf6N2E2_2835 -0.1
Pf6N2E2_3492 -0.2
Pf6N2E2_5999 -0.5
4-hydroxybenzoyl-CoA thioesterase:
4-hydroxybenzoyl-CoA + H2O→4-hydroxybenzoate + coenzyme A + H+ (EC 3.1.2.23)
Pf6N2E2_5538 -1.5

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information