MetaCyc Pathway: serotonin degradation in Sinorhizobium meliloti 1021

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Reactions and Genes L-Fucose (C)
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Aryl sulfotransferase:
serotonin + 3'-phosphoadenylyl-sulfate→serotonin O-sulfate + adenosine 3',5'-bisphosphate + H+ (EC 2.8.2.1)
No genes
Monoamine oxidase:
serotonin + dioxygen + H2O→5-hydroxyindole acetaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.4)
No genes
5-hydroxyindole acetaldehyde + L-cysteine→5-hydroxyindole thiazolidine carboxylate + H+ + H2O (spontaneous)
No genes
Aldehyde dehydrogenase (NAD(+)):
5-hydroxyindole acetaldehyde + NAD+ + H2O→5-hydroxyindole acetate + NADH + 2 H+ (EC 1.2.1.3)
SM_b20978 -0.1
SM_b21110 -4.2
SM_b21301 -0.1
SMa0220 -0.0
SMa0796 +0.1
SMa1844 -0.2
SMa1848 -0.1
SMa2213 +0.1
SMc01971 -0.0
SMc02689 -0.2
SMc04397 -0.1
Alcohol dehydrogenase (in reverse):
5-hydroxyindole acetaldehyde + NADH + H+→5-hydroxytryptophol + NAD+ (EC 1.1.1.1)
SM_b20147 +0.1
SM_b20170 N.D.
SMa0263 +0.1
SMa1296 +0.1
SMa2113 +0.4
SMc00105 +0.2
SMc00680 -0.3
SMc01270 N.D.
SMc01582 +0.1
SMc01816 +0.0
SMc03929 -0.3
SMc04270 N.D.
Aryl sulfotransferase:
5-hydroxytryptophol + 3'-phosphoadenylyl-sulfate→5-hydroxytryptophol sulfate + adenosine 3',5'-bisphosphate + H+ (EC 2.8.2.1)
No genes
Glucuronosyltransferase:
5-hydroxytryptophol + UDP-α-D-glucuronate→5-hydroxytryptophol glucuronide + H+ + UDP (EC 2.4.1.17)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information