MetaCyc Pathway: D-glucuronate degradation II in Sinorhizobium meliloti 1021

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Reactions and Genes L-Arabinose (C)
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Uronate dehydrogenase:
β-D-glucuronate + NAD+→D-glucaro-1,5-lactone + NADH + H+ (EC 1.1.1.203)
SMc04145 -0.1
D-glucaro-1,5-lactone→D-glucaro-1,4-lactone (spontaneous) (EC 5.4.1.4)
No genes
D-glucaro-1,4-lactone→5-dehydro-4-deoxy-D-glucarate + H+ (EC 5.5.1.27)
No genes
5-dehydro-4-deoxyglucarate dehydratase:
5-dehydro-4-deoxy-D-glucarate + H+→2,5-dioxopentanoate + CO2 + H2O (EC 4.2.1.41)
SMa1440 -0.1
2,5-dioxovalerate dehydrogenase:
2,5-dioxopentanoate + NADP+ + H2O→2-oxoglutarate + NADPH + 2 H+ (EC 1.2.1.26)
SM_b20262 -0.1
SM_b20891 -3.7

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information