MetaCyc Pathway: ketogenesis in Marinobacter adhaerens HP15

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Reactions and Genes L-Phenylalanine as (N)
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Acetyl-CoA C-acyltransferase:
2 acetyl-CoA→acetoacetyl-CoA + coenzyme A (EC 2.3.1.16; 2.3.1.9)
HP15_1009 +0.2
HP15_1233 +0.2
HP15_1513 -0.1
HP15_2344 +0.2
HP15_2423 -0.1
HP15_2695 -3.3
HP15_2996 -0.6
HP15_35 -0.3
HP15_3943 -0.0
HP15_49 +0.2
HP15_5 +0.3
Hydroxymethylglutaryl-CoA synthase:
acetoacetyl-CoA + acetyl-CoA + H2O→(S)-3-hydroxy-3-methylglutaryl-CoA + coenzyme A + H+ (EC 2.3.3.10)
No genes
Hydroxymethylglutaryl-CoA lyase:
(S)-3-hydroxy-3-methylglutaryl-CoA→acetyl-CoA + acetoacetate (EC 4.1.3.4)
HP15_1001 N.D.
HP15_2608 +0.3
HP15_4178 +0.1
3-hydroxybutyrate dehydrogenase (in reverse):
acetoacetate + NADH + H+→(R)-3-hydroxybutanoate + NAD+ (EC 1.1.1.30)
HP15_3798 -0.1
Acetoacetate decarboxylase:
acetoacetate + H+→acetone + CO2 (EC 4.1.1.4)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information