MetaCyc Pathway: (2S)-ethylmalonyl-CoA biosynthesis in Marinobacter adhaerens HP15

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Reactions and Genes L-Phenylalanine as (N)
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Acetyl-CoA C-acyltransferase:
2 acetyl-CoA→acetoacetyl-CoA + coenzyme A (EC 2.3.1.16; 2.3.1.9)
HP15_1009 +0.2
HP15_1233 +0.2
HP15_1513 -0.1
HP15_2344 +0.2
HP15_2423 -0.1
HP15_2695 -3.3
HP15_2996 -0.6
HP15_35 -0.3
HP15_3943 -0.0
HP15_49 +0.2
HP15_5 +0.3
Acetoacetyl-CoA reductase (in reverse):
acetoacetyl-CoA + NADPH + H+→(3R)-3-hydroxybutanoyl-CoA + NADP+ (EC 1.1.1.36)
HP15_2784 -0.0
3-hydroxybutyryl-CoA dehydratase:
(3R)-3-hydroxybutanoyl-CoA→crotonyl-CoA + H2O (EC 4.2.1.55)
HP15_2702 -2.9
crotonyl-CoA + CO2 + NADPH→(2S)-ethylmalonyl-CoA + NADP+ (EC 1.3.1.85)
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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information