MetaCyc Pathway: superpathway of coenzyme A biosynthesis II (plants) in Shewanella loihica PV-4

Reactions and Genes	acetate (C)
3-methyl-2-oxobutanoate hydroxymethyltransferase: 3-methyl-2-oxobutanoate + a 5,10-methylenetetrahydrofolate + H2O→2-dehydropantoate + a tetrahydrofolate (EC 2.1.2.11)
Shew_3133	N.D.
Propionate--CoA ligase: propanoate + ATP + coenzyme A→propanoyl-CoA + AMP + diphosphate (EC 6.2.1.17)
Shew_1533	+2.9
Shew_2568	+1.5
2-dehydropantoate 2-reductase (in reverse): 2-dehydropantoate + NADPH + H+→(R)-pantoate + NADP+ (EC 1.1.1.169)
Shew_0288	-9.0
Shew_2895	-1.6
propanoyl-CoA + an oxidized electron-transfer flavoprotein + H+→acryloyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.1)
Shew_1669	+1.0
Shew_2868	+0.4
acryloyl-CoA + H2O→3-hydroxypropanoyl-CoA (EC 4.2.1.116)
Shew_1670	-0.6
3-hydroxyisobutyryl-CoA hydrolase: 3-hydroxypropanoyl-CoA + H2O→3-hydroxypropanoate + coenzyme A + H+ (EC 3.1.2.4)
Shew_1671	-1.3
3-hydroxypropionate dehydrogenase: 3-hydroxypropanoate + NAD+→3-oxopropanoate + NADH + H+ (EC 1.1.1.59)
No genes
Beta-alanine--pyruvate transaminase: 3-oxopropanoate + L-alanine→β-alanine + pyruvate (EC 2.6.1.18)
Shew_0966	+0.4
Pantoate--beta-alanine ligase: β-alanine + (R)-pantoate + ATP→(R)-pantothenate + AMP + diphosphate + H+ (EC 6.3.2.1)
Shew_3134	N.D.
Pantothenate kinase: (R)-pantothenate + ATP→(R)-4'-phosphopantothenate + ADP + H+ (EC 2.7.1.33)
Shew_0143	N.D.

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information