MetaCyc Pathway: reductive TCA cycle II in Bacteroides thetaiotaomicron VPI-5482

Reactions and Genes	PEG (Day 3) - Cage2;Mouse1
2-oxoglutarate synthase (in reverse): succinyl-CoA + CO2 + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→2-oxoglutarate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster (EC 1.2.7.3)
BT0329	N.D.
BT0330	N.D.
BT0331	N.D.
BT0332	N.D.
BT0333	N.D.
BT2836	+0.7
BT2837	-0.2
2-oxoglutarate carboxylase: 2-oxoglutarate + ATP + CO2 + H2O→oxalosuccinate + ADP + 2 H+ + phosphate (EC 6.4.1.7)
No genes
oxalosuccinate + NADH + H+→D-threo-isocitrate + NAD+
BT2071	-0.7
Aconitate hydratase (in reverse): D-threo-isocitrate→cis-aconitate + H2O (EC 4.2.1.3)
BT2072	+2.1
Aconitate hydratase (in reverse): cis-aconitate + H2O→citrate (EC 4.2.1.3)
BT2072	+2.1
Citrate--CoA ligase: citrate + ATP + coenzyme A→(3S)-citryl-CoA + ADP + phosphate (EC 6.2.1.18)
No genes
Citryl-CoA lyase: (3S)-citryl-CoA→acetyl-CoA + oxaloacetate (EC 4.1.3.34)
No genes
Malate dehydrogenase (in reverse): oxaloacetate + NADH + H+→(S)-malate + NAD+ (EC 1.1.1.37; 1.1.1.38)
BT2510	-0.5
BT3911	-0.5
Pyruvate synthase (in reverse): acetyl-CoA + CO2 + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→pyruvate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster (EC 1.2.7.1)
BT1747	-1.6
Fumarate hydratase: (S)-malate→fumarate + H2O (EC 4.2.1.2)
BT2256	N.D.
Succinate dehydrogenase (ubiquinone): fumarate[in] + a menaquinol→succinate[in] + a menaquinone (EC 1.3.5.1)
No genes
Succinate--CoA ligase (ADP-forming): succinate + ATP + coenzyme A→succinyl-CoA + ADP + phosphate (EC 6.2.1.5)
BT0787	+0.0
BT0788	-0.3

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information