MetaCyc Pathway: pyrimidine deoxyribonucleotides de novo biosynthesis II in Klebsiella michiganensis M5al

Reactions and Genes	D-Glucose (C) with ammonium chloride; anaerobic; 8 days
CTP + formate + H+→dCTP + CO2 + H2O (EC 1.1.98.6)
BWI76_RS02935	-4.7
UTP + formate + H+→dUTP + CO2 + H2O (EC 1.1.98.6)
BWI76_RS02935	-4.7
dCTP deaminase: dCTP + H+ + H2O→dUTP + ammonium (EC 3.5.4.13)
BWI76_RS19120	N.D.
dUTP diphosphatase: dUTP + H2O→dUMP + diphosphate + H+ (EC 3.6.1.23; 3.6.1.9)
BWI76_RS20020	-0.1
BWI76_RS27375	N.D.
Thymidylate synthase: dUMP + a 5,10-methylenetetrahydrofolate→dTMP + a 7,8-dihydrofolate (EC 2.1.1.45)
BWI76_RS14320	-0.2
T(2)-induced deoxynucleotide kinase: dTMP + ATP→dTDP + ADP (EC 2.7.4.12; 2.7.4.13; 2.7.4.9)
BWI76_RS11115	N.D.
Nucleoside-diphosphate kinase: dTDP + ATP→dTTP + ADP (EC 2.7.4.6)
BWI76_RS06840	N.D.
BWI76_RS21100	-0.3

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information