MetaCyc Pathway: L-phenylalanine degradation IV (mammalian, via side chain) in Pseudomonas fluorescens SBW25-INTG

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Reactions and Genes 4-Hydroxybenzoic Acid (C) and Ammonium chloride (N); with MOPS
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Aromatic-L-amino-acid decarboxylase:
L-phenylalanine + H+→2-phenylethylamine + CO2 (EC 4.1.1.28; 4.1.1.53)
No genes
Aspartate transaminase:
L-phenylalanine + 2-oxoglutarate→3-phenyl-2-oxopropanoate + L-glutamate (EC 2.6.1.1; 2.6.1.27; 2.6.1.57)
PFLU_RS04475 -0.5
PFLU_RS08100 -0.2
PFLU_RS08510 -0.1
PFLU_RS09125 -0.1
PFLU_RS10980 +0.2
PFLU_RS13455 +0.3
PFLU_RS15480 +0.0
PFLU_RS16880 +0.1
PFLU_RS17055 -0.0
PFLU_RS17810 +0.1
PFLU_RS19680 +0.3
PFLU_RS20660 -0.7
PFLU_RS21080 -0.1
PFLU_RS21355 -0.0
PFLU_RS21880 -0.0
PFLU_RS22640 -0.5
PFLU_RS22895 -0.4
PFLU_RS24775 +0.0
PFLU_RS25195 +0.2
PFLU_RS29405 +0.1
PFLU_RS29850 -0.0
4-hydroxyphenylpyruvate dioxygenase:
3-phenyl-2-oxopropanoate + dioxygen→(2-hydroxyphenyl)acetate + CO2 (EC 1.13.11.27)
PFLU_RS14610 -0.2
PFLU_RS26370 +0.3
Indolelactate dehydrogenase (in reverse):
3-phenyl-2-oxopropanoate + NADH + H+→(R)-3-(phenyl)lactate + NAD+ (EC 1.1.1.110)
No genes
Primary-amine oxidase:
2-phenylethylamine + dioxygen + H2O→phenylacetaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.21; 1.4.3.4)
PFLU_RS19865 +0.2
Phenylacetaldehyde dehydrogenase:
phenylacetaldehyde + NAD+ + H2O→phenylacetate + NADH + 2 H+ (EC 1.2.1.39)
PFLU_RS15055 +0.1
PFLU_RS15075 +0.5
PFLU_RS16030 +0.2
PFLU_RS26745 -3.7
Phenylacetate--CoA ligase:
phenylacetate + ATP + coenzyme A→phenylacetyl-CoA + AMP + diphosphate (EC 6.2.1.30)
PFLU_RS06820 -0.1
Glutamine N-phenylacetyltransferase:
phenylacetyl-CoA + L-glutamine→α-N-phenylacetyl-L-glutamine + coenzyme A + H+ (EC 2.3.1.14)
No genes
phenylacetyl-CoA + glycine→phenylacetylglycine + coenzyme A + H+ (EC 2.3.1.192)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information