MetaCyc Pathway: serotonin degradation in Pseudomonas fluorescens SBW25-INTG

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Reactions and Genes D,L-Malic Acid (C) and Ammonium chloride (N); with TAPS; with chloride
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Aryl sulfotransferase:
serotonin + 3'-phosphoadenylyl-sulfate→serotonin O-sulfate + adenosine 3',5'-bisphosphate + H+ (EC 2.8.2.1)
No genes
Monoamine oxidase:
serotonin + dioxygen + H2O→5-hydroxyindole acetaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.4)
PFLU_RS19865 +0.7
5-hydroxyindole acetaldehyde + L-cysteine→5-hydroxyindole thiazolidine carboxylate + H+ + H2O (spontaneous)
No genes
Aldehyde dehydrogenase (NAD(+)):
5-hydroxyindole acetaldehyde + NAD+ + H2O→5-hydroxyindole acetate + NADH + 2 H+ (EC 1.2.1.3)
PFLU_RS02715 +0.3
PFLU_RS04240 -0.1
PFLU_RS07400 +0.5
PFLU_RS09895 -0.9
PFLU_RS11535 +0.1
PFLU_RS15055 +0.6
PFLU_RS15075 +0.2
PFLU_RS15110 +0.7
PFLU_RS19825 +0.2
PFLU_RS20100 +0.1
PFLU_RS26745 -2.5
PFLU_RS29420 -0.8
Alcohol dehydrogenase (in reverse):
5-hydroxyindole acetaldehyde + NADH + H+→5-hydroxytryptophol + NAD+ (EC 1.1.1.1)
PFLU_RS06395 -0.3
PFLU_RS06965 -0.4
PFLU_RS10840 -0.1
PFLU_RS11825 +0.3
PFLU_RS20115 +0.2
PFLU_RS22935 -0.1
PFLU_RS27395 -0.2
Aryl sulfotransferase:
5-hydroxytryptophol + 3'-phosphoadenylyl-sulfate→5-hydroxytryptophol sulfate + adenosine 3',5'-bisphosphate + H+ (EC 2.8.2.1)
No genes
Glucuronosyltransferase:
5-hydroxytryptophol + UDP-α-D-glucuronate→5-hydroxytryptophol glucuronide + H+ + UDP (EC 2.4.1.17)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information