MetaCyc Pathway: phosphopantothenate biosynthesis III (archaea) in Klebsiella michiganensis M5al

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Reactions and Genes Fungal_growth_media_mCAFEs_v1 with nitrate 20 mM
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3-methyl-2-oxobutanoate hydroxymethyltransferase:
3-methyl-2-oxobutanoate + 5,10-methylene-tetrahydromethanopterin + H2O→2-dehydropantoate + tetrahydromethanopterin (EC 2.1.2.11)
BWI76_RS04995 -2.3
2-dehydropantoate 2-reductase (in reverse):
2-dehydropantoate + NADPH + H+→(R)-pantoate + NADP+ (EC 1.1.1.169)
BWI76_RS00990 -4.7
BWI76_RS06405 -1.4
BWI76_RS14790 N.D.
(R)-pantoate + ATP→(R)-4-phosphopantoate + ADP + H+ (EC 2.7.1.169)
No genes
(R)-4-phosphopantoate + β-alanine + ATP→(R)-4'-phosphopantothenate + AMP + diphosphate + H+ (EC 6.3.2.36)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information