MetaCyc Pathway: superpathway of heme b biosynthesis from glycine in Klebsiella michiganensis M5al

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Reactions and Genes Fungal_growth_media_mCAFEs_v1 with Aluminum chloride 2 mM
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5-aminolevulinate synthase:
glycine + H+ + succinyl-CoA→5-aminolevulinate + CO2 + coenzyme A (EC 2.3.1.37)
No genes
Porphobilinogen synthase:
2 5-aminolevulinate→porphobilinogen + H+ + 2 H2O (EC 4.2.1.24)
BWI76_RS06090 N.D.
Hydroxymethylbilane synthase:
4 porphobilinogen + H2O→preuroporphyrinogen + 4 ammonium (EC 2.5.1.61)
BWI76_RS01180 N.D.
Uroporphyrinogen-III synthase:
preuroporphyrinogen→uroporphyrinogen-III + H2O (EC 4.2.1.75)
BWI76_RS01175 N.D.
Uroporphyrinogen decarboxylase:
uroporphyrinogen-III + 4 H+→coproporphyrinogen III + 4 CO2 (EC 4.1.1.37)
BWI76_RS01570 N.D.
Coproporphyrinogen oxidase:
coproporphyrinogen III + dioxygen + 2 H+→protoporphyrinogen IX + 2 CO2 + 2 H2O (EC 1.3.3.3)
BWI76_RS20740 -1.6
Protoporphyrinogen oxidase:
protoporphyrinogen IX + 3 dioxygen→protoporphyrin IX + 3 hydrogen peroxide (EC 1.3.3.4)
No genes
protoporphyrin IX + Fe2+→protoheme + 2 H+ (EC 4.98.1.1)
BWI76_RS06845 N.D.
BWI76_RS10825 -0.4
BWI76_RS20710 -0.7

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information