MetaCyc Pathway: superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae) in Pseudomonas fluorescens FW300-N2E2

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Reactions and Genes Cobalt chloride 0.6 mM
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Homoserine O-acetyltransferase:
L-homoserine + acetyl-CoA→O-acetyl-L-homoserine + coenzyme A (EC 2.3.1.31)
Pf6N2E2_4596 -0.2
Pf6N2E2_4597 +0.1
Sulfate adenylyltransferase:
sulfate + ATP + H+→adenosine 5'-phosphosulfate + diphosphate (EC 2.7.7.4)
Pf6N2E2_5257 -0.2
Pf6N2E2_5258 -0.4
Adenylyl-sulfate kinase:
adenosine 5'-phosphosulfate + ATP→3'-phosphoadenylyl-sulfate + ADP + H+ (EC 2.7.1.25)
Pf6N2E2_3654 +0.3
Pf6N2E2_5258 -0.4
Phosphoadenylyl-sulfate reductase (thioredoxin) (in reverse):
3'-phosphoadenylyl-sulfate + a reduced thioredoxin→sulfite + adenosine 3',5'-bisphosphate + an oxidized thioredoxin + 2 H+ (EC 1.8.4.8)
Pf6N2E2_6054 N.D.
Sulfite reductase (NADPH) (in reverse):
sulfite + 3 NADPH + 5 H+→hydrogen sulfide + 3 NADP+ + 3 H2O (EC 1.8.1.2)
Pf6N2E2_1511 +0.0
Pf6N2E2_2073 -0.8
Pf6N2E2_3335 +1.1
O-acetylhomoserine aminocarboxypropyltransferase:
O-acetyl-L-homoserine + hydrogen sulfide→L-homocysteine + acetate + H+ (EC 2.5.1.49)
Pf6N2E2_1768 +0.2
Pf6N2E2_1876 -0.1
Pf6N2E2_77 +0.4
Cystathionine beta-synthase:
L-homocysteine + L-serine→L-cystathionine + H2O (EC 4.2.1.22)
No genes
Cysteine-S-conjugate beta-lyase:
L-cystathionine + H2O→L-homocysteine + ammonium + pyruvate (EC 4.4.1.13)
No genes
Cystathionine gamma-lyase:
L-cystathionine + H2O→L-cysteine + 2-oxobutanoate + ammonium (EC 4.4.1.1)
Pf6N2E2_5896 -0.1
Cystathionine gamma-synthase:
L-cysteine + O-succinyl-L-homoserine→L-cystathionine + H+ + succinate (EC 2.5.1.48)
Pf6N2E2_4958 +0.2
Pf6N2E2_77 +0.4

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information