MetaCyc Pathway: octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast) in Pseudomonas fluorescens FW300-N2E2

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Reactions and Genes Cobalt chloride 0.6 mM
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Beta-ketoacyl-acyl-carrier-protein synthase II:
an acetyl-[acp] + a malonyl-[acp] + H+→an acetoacetyl-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
Pf6N2E2_1178 +0.0
Pf6N2E2_3726 -0.1
Pf6N2E2_3729 +0.4
Pf6N2E2_5870 N.D.
Pf6N2E2_5954 N.D.
Pf6N2E2_835 -0.4
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
an acetoacetyl-[acp] + NADPH + H+→a (3R)-3-hydroxybutanoyl-[acp] + NADP+ (EC 1.1.1.100)
Pf6N2E2_1004 -0.2
Pf6N2E2_1181 +0.2
Pf6N2E2_1257 +0.0
Pf6N2E2_1323 -0.0
Pf6N2E2_1747 -0.0
Pf6N2E2_1925 -0.0
Pf6N2E2_1928 +0.2
Pf6N2E2_3493 +1.5
Pf6N2E2_3704 -0.0
Pf6N2E2_3728 +0.1
Pf6N2E2_383 +0.3
Pf6N2E2_3916 -0.2
Pf6N2E2_394 +0.1
Pf6N2E2_4183 +0.1
Pf6N2E2_5206 +0.1
Pf6N2E2_5209 -0.2
Pf6N2E2_5603 +0.3
Pf6N2E2_5952 N.D.
Pf6N2E2_5967 +0.6
Pf6N2E2_6050 -0.1
Pf6N2E2_686 +0.2
Pf6N2E2_853 +0.1
Pf6N2E2_990 -0.5
Pf6N2E2_995 -0.3
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxybutanoyl-[acp]→a (2E)-but-2-enoyl-[acp] + H2O (EC 4.2.1.59)
Pf6N2E2_3058 N.D.
Pf6N2E2_5871 N.D.
Enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) (in reverse):
a (2E)-but-2-enoyl-[acp] + NADPH + H+→a butanoyl-[acp] + NADP+ (EC 1.3.1.10; 1.3.1.104; 1.3.1.39)
Pf6N2E2_1446 -0.6
Beta-ketoacyl-acyl-carrier-protein synthase II:
a butanoyl-[acp] + a malonyl-[acp] + H+→a 3-oxohexanoyl-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
Pf6N2E2_1178 +0.0
Pf6N2E2_3726 -0.1
Pf6N2E2_3729 +0.4
Pf6N2E2_5870 N.D.
Pf6N2E2_5954 N.D.
Pf6N2E2_835 -0.4
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxohexanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxyhexanoyl-[acp] + NADP+ (EC 1.1.1.100)
Pf6N2E2_1004 -0.2
Pf6N2E2_1181 +0.2
Pf6N2E2_1257 +0.0
Pf6N2E2_1323 -0.0
Pf6N2E2_1747 -0.0
Pf6N2E2_1925 -0.0
Pf6N2E2_1928 +0.2
Pf6N2E2_3493 +1.5
Pf6N2E2_3704 -0.0
Pf6N2E2_3728 +0.1
Pf6N2E2_383 +0.3
Pf6N2E2_3916 -0.2
Pf6N2E2_394 +0.1
Pf6N2E2_4183 +0.1
Pf6N2E2_5206 +0.1
Pf6N2E2_5209 -0.2
Pf6N2E2_5603 +0.3
Pf6N2E2_5952 N.D.
Pf6N2E2_5967 +0.6
Pf6N2E2_6050 -0.1
Pf6N2E2_686 +0.2
Pf6N2E2_853 +0.1
Pf6N2E2_990 -0.5
Pf6N2E2_995 -0.3
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxyhexanoyl-[acp]→a (2E)-hex-2-enoyl-[acp] + H2O (EC 4.2.1.59)
Pf6N2E2_3058 N.D.
Pf6N2E2_5871 N.D.
Enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) (in reverse):
a (2E)-hex-2-enoyl-[acp] + NADPH + H+→a hexanoyl-[acp] + NADP+ (EC 1.3.1.10; 1.3.1.104; 1.3.1.39)
Pf6N2E2_1446 -0.6
Beta-ketoacyl-acyl-carrier-protein synthase II:
a hexanoyl-[acp] + a malonyl-[acp] + H+→a 3-oxooctanoyl-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
Pf6N2E2_1178 +0.0
Pf6N2E2_3726 -0.1
Pf6N2E2_3729 +0.4
Pf6N2E2_5870 N.D.
Pf6N2E2_5954 N.D.
Pf6N2E2_835 -0.4
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxooctanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxyoctanoyl-[acp] + NADP+ (EC 1.1.1.100)
Pf6N2E2_1004 -0.2
Pf6N2E2_1181 +0.2
Pf6N2E2_1257 +0.0
Pf6N2E2_1323 -0.0
Pf6N2E2_1747 -0.0
Pf6N2E2_1925 -0.0
Pf6N2E2_1928 +0.2
Pf6N2E2_3493 +1.5
Pf6N2E2_3704 -0.0
Pf6N2E2_3728 +0.1
Pf6N2E2_383 +0.3
Pf6N2E2_3916 -0.2
Pf6N2E2_394 +0.1
Pf6N2E2_4183 +0.1
Pf6N2E2_5206 +0.1
Pf6N2E2_5209 -0.2
Pf6N2E2_5603 +0.3
Pf6N2E2_5952 N.D.
Pf6N2E2_5967 +0.6
Pf6N2E2_6050 -0.1
Pf6N2E2_686 +0.2
Pf6N2E2_853 +0.1
Pf6N2E2_990 -0.5
Pf6N2E2_995 -0.3
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxyoctanoyl-[acp]→a (2E)-oct-2-enoyl-[acp] + H2O (EC 4.2.1.59)
Pf6N2E2_3058 N.D.
Pf6N2E2_5871 N.D.
Enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) (in reverse):
a (2E)-oct-2-enoyl-[acp] + NADPH + H+→an octanoyl-[acp] + NADP+ (EC 1.3.1.10; 1.3.1.104; 1.3.1.39)
Pf6N2E2_1446 -0.6

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information