MetaCyc Pathway: superpathway of cardiolipin biosynthesis (bacteria) in Pseudomonas fluorescens FW300-N2E2

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Reactions and Genes Cobalt chloride 0.6 mM
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Glycerol-3-phosphate dehydrogenase (NAD(P)(+)) (in reverse):
glycerone phosphate + NAD(P)H + H+→sn-glycerol 3-phosphate + NAD(P)+ (EC 1.1.1.94)
Pf6N2E2_5875 N.D.
a fatty acyl-[acyl-carrier protein] + phosphate→an acyl phosphate + a soluble [acyl-carrier protein] (EC 2.3.1.274)
No genes
Glycerol-3-phosphate O-acyltransferase:
sn-glycerol 3-phosphate + an acyl-[acyl-carrier protein]→a 2-lysophosphatidate + a soluble [acyl-carrier protein] (EC 2.3.1.15)
Pf6N2E2_3087 -0.2
Pf6N2E2_4795 +3.6
Pf6N2E2_5950 +0.4
an acyl phosphate + sn-glycerol 3-phosphate→a 2-lysophosphatidate + phosphate (EC 2.3.1.275)
No genes
1-acylglycerol-3-phosphate O-acyltransferase:
a 2-lysophosphatidate + an acyl-[acyl-carrier protein]→a phosphatidate + a soluble [acyl-carrier protein] (EC 2.3.1.51)
Pf6N2E2_2816 N.D.
Pf6N2E2_4192 N.D.
Pf6N2E2_4950 -0.6
Pf6N2E2_5765 +0.1
Pf6N2E2_6003 -0.0
Phosphatidate cytidylyltransferase:
a phosphatidate + CTP + H+→a CDP-diacylglycerol + diphosphate (EC 2.7.7.41)
Pf6N2E2_3064 N.D.
Pf6N2E2_4949 -0.0
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase:
a CDP-diacylglycerol + sn-glycerol 3-phosphate→a phosphatidylglycerophosphate + CMP + H+ (EC 2.7.8.5)
Pf6N2E2_2020 N.D.
Pf6N2E2_4954 +0.4
CDP-diacylglycerol--serine O-phosphatidyltransferase:
a CDP-diacylglycerol + L-serine→a phosphatidylserine + CMP + H+ (EC 2.7.8.8)
Pf6N2E2_1137 -0.3
Pf6N2E2_5178 -1.3
a CDP-diacylglycerol + a phosphatidylglycerol→a cardiolipin + CMP + H+ (EC 2.7.8.41)
Pf6N2E2_2810 -1.5
Pf6N2E2_4257 -0.1
Pf6N2E2_4385 -0.5
Pf6N2E2_4901 +0.0
Phosphatidylglycerophosphatase:
a phosphatidylglycerophosphate + H2O→a phosphatidylglycerol + phosphate (EC 3.1.3.27)
Pf6N2E2_4925 N.D.
Phosphatidylserine decarboxylase:
a phosphatidylserine + H+→a phosphatidylethanolamine + CO2 (EC 4.1.1.65)
Pf6N2E2_3628 N.D.
2 a phosphatidylglycerol→a cardiolipin + glycerol (EC 2.7.8.41)
Pf6N2E2_4901 +0.0
a phosphatidylethanolamine + a phosphatidylglycerol→a cardiolipin + ethanolamine (EC 2.7.8.41)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information