MetaCyc Pathway: superpathway of heme b biosynthesis from uroporphyrinogen-III in Pseudomonas fluorescens SBW25-INTG

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Reactions and Genes D,L-Malic Acid (C) and Ammonium chloride (N); with MOPS; with chloride
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Uroporphyrinogen decarboxylase:
uroporphyrinogen-III + 4 H+→coproporphyrinogen III + 4 CO2 (EC 4.1.1.37)
PFLU_RS02055 N.D.
coproporphyrinogen III + 2 S-adenosyl-L-methionine→protoporphyrinogen IX + 2 CO2 + 2 5'-deoxyadenosine + 2 L-methionine (EC 1.3.98.3)
PFLU_RS17650 -0.1
PFLU_RS22385 -1.4
Coproporphyrinogen oxidase:
coproporphyrinogen III + dioxygen + 2 H+→protoporphyrinogen IX + 2 CO2 + 2 H2O (EC 1.3.3.3)
PFLU_RS00115 N.D.
protoporphyrinogen IX[in] + 3 a ubiquinone→protoporphyrin IX[in] + 3 a ubiquinol (EC 1.3.5.3)
No genes
protoporphyrinogen IX[in] + 3 a menaquinone→protoporphyrin IX[in] + 3 a menaquinol (EC 1.3.5.3)
No genes
protoporphyrin IX + Fe2+→protoheme + 2 H+ (EC 4.98.1.1)
PFLU_RS03745 N.D.
PFLU_RS14225 +0.0

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information