MetaCyc Pathway: phosphopantothenate biosynthesis I in Klebsiella michiganensis M5al

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Reactions and Genes Fungal_growth_media_mCAFEs_v1 with Aluminum chloride 2 mM
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3-methyl-2-oxobutanoate hydroxymethyltransferase:
3-methyl-2-oxobutanoate + a 5,10-methylenetetrahydrofolate + H2O→2-dehydropantoate + a tetrahydrofolate (EC 2.1.2.11)
BWI76_RS04995 -0.6
2-dehydropantoate 2-reductase (in reverse):
2-dehydropantoate + NADPH + H+→(R)-pantoate + NADP+ (EC 1.1.1.169)
BWI76_RS00990 -4.0
BWI76_RS06405 -1.1
BWI76_RS14790 N.D.
Pantoate--beta-alanine ligase:
(R)-pantoate + β-alanine + ATP→(R)-pantothenate + AMP + diphosphate + H+ (EC 6.3.2.1)
BWI76_RS04990 -2.0
Pantothenate kinase:
(R)-pantothenate + ATP→(R)-4'-phosphopantothenate + ADP + H+ (EC 2.7.1.33)
BWI76_RS01430 N.D.

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information