MetaCyc Pathway: superpathway of adenosylcobalamin salvage from cobinamide II in Klebsiella michiganensis M5al

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Reactions and Genes Fungal_growth_media_mCAFEs_v1 with Thallium(I) acetate 0.05 mg/mL
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Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase:
5,6-dimethylbenzimidazole + β-nicotinate D-ribonucleotide→α-ribazole 5'-phosphate + nicotinate + H+ (EC 2.4.2.21)
BWI76_RS23000 -0.2
Cob(I)yrinic acid a,c-diamide adenosyltransferase:
cob(II)inamide + a [corrinoid adenosyltransferase]→[corrinoid adenosyltranferase]-cob(II)inamide (EC 2.5.1.17)
BWI76_RS08445 -0.2
BWI76_RS11900 +0.7
BWI76_RS20810 +1.8
BWI76_RS23165 +0.1
Cob(I)yrinic acid a,c-diamide adenosyltransferase:
2 [corrinoid adenosyltranferase]-cob(II)inamide + a [reduced flavoprotein]→2 [corrinoid adenosyltranferase]-cob(I)inamide + an [oxidized flavoprotein] + 2 H+ (spontaneous) (EC 2.5.1.17)
BWI76_RS08445 -0.2
BWI76_RS11900 +0.7
BWI76_RS20810 +1.8
BWI76_RS23165 +0.1
Cob(I)yrinic acid a,c-diamide adenosyltransferase:
2 [corrinoid adenosyltranferase]-cob(I)inamide + 2 ATP + 2 H+→2 adenosylcobinamide + 2 a [corrinoid adenosyltransferase] + 2 triphosphate (EC 2.5.1.17)
BWI76_RS08445 -0.2
BWI76_RS11900 +0.7
BWI76_RS20810 +1.8
BWI76_RS23165 +0.1
Adenosylcobinamide hydrolase:
adenosylcobinamide + H2O→adenosylcobyrate + (R)-1-aminopropan-2-ol (EC 3.5.1.90)
No genes
Adenosylcobinamide-phosphate synthase:
adenosylcobyrate + (R)-1-amino-2-propanol O-2-phosphate + ATP→adenosyl-cobinamide phosphate + ADP + H+ + phosphate (EC 6.3.1.10)
BWI76_RS23085 +0.1
Adenosylcobinamide-phosphate guanylyltransferase:
adenosyl-cobinamide phosphate + GTP + H+→adenosylcobinamide-GDP + diphosphate (EC 2.7.7.62)
BWI76_RS18755 +0.4
BWI76_RS23005 +1.3
Adenosylcobinamide-GDP ribazoletransferase:
adenosylcobinamide-GDP + α-ribazole 5'-phosphate→adenosylcobalamin 5'-phosphate + GMP + H+ (EC 2.7.8.26)
BWI76_RS18750 N.D.
Alpha-ribazole phosphatase:
adenosylcobalamin 5'-phosphate + H2O→adenosylcobalamin + phosphate (EC 3.1.3.73)
BWI76_RS08055 N.D.

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information