| Reactions and Genes | Fungal_growth_media_mCAFEs_v1 with Thallium(I) acetate 0.05 mg/mL |
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Glutamate--tRNA ligase:
L-glutamate + ATP + a tRNAglu→an L-glutamyl-[tRNAGlu] + AMP + diphosphate (EC 6.1.1.17) |
| BWI76_RS20570 | N.D. |
Riboflavin kinase:
riboflavin + ATP→FMN + ADP + H+ (EC 2.7.1.26) |
| BWI76_RS04335 | N.D. |
| L-threonine + ATP→L-threonine 3-O-phosphate + ADP + H+ (EC 2.7.1.177) |
| BWI76_RS23205 | -0.2 |
Threonine-phosphate decarboxylase:
L-threonine 3-O-phosphate + H+→(R)-1-amino-2-propanol O-2-phosphate + CO2 (EC 4.1.1.81) |
| BWI76_RS23210 | +0.7 |
| FMN + NAD(P)H + 2 H+→FMNH2 + NAD(P)+ (EC 1.5.1.39) |
| BWI76_RS01350 | +2.2 |
| BWI76_RS09905 | +0.3 |
Glutamyl-tRNA reductase (in reverse):
an L-glutamyl-[tRNAGlu] + NADPH + H+→(S)-4-amino-5-oxopentanoate + a tRNAglu + NADP+ (EC 1.2.1.70) |
| BWI76_RS17440 | N.D. |
Glutamate-1-semialdehyde 2,1-aminomutase:
(S)-4-amino-5-oxopentanoate→5-aminolevulinate (EC 5.4.3.8) |
| BWI76_RS05145 | N.D. |
| FMNH2 + dioxygen→5,6-dimethylbenzimidazole + dialurate + D-erythrose 4-phosphate (EC 1.13.11.79) |
| No genes |
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase:
5,6-dimethylbenzimidazole + β-nicotinate D-ribonucleotide→α-ribazole 5'-phosphate + nicotinate + H+ (EC 2.4.2.21) |
| BWI76_RS23000 | -0.2 |
Porphobilinogen synthase:
2 5-aminolevulinate→porphobilinogen + H+ + 2 H2O (EC 4.2.1.24) |
| BWI76_RS06090 | N.D. |
Hydroxymethylbilane synthase:
4 porphobilinogen + H2O→preuroporphyrinogen + 4 ammonium (EC 2.5.1.61) |
| BWI76_RS01180 | N.D. |
Uroporphyrinogen-III synthase:
preuroporphyrinogen→uroporphyrinogen-III + H2O (EC 4.2.1.75) |
| BWI76_RS01175 | N.D. |
Uroporphyrinogen-III C-methyltransferase:
uroporphyrinogen-III + S-adenosyl-L-methionine→precorrin-1 + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.107) |
| BWI76_RS11435 | -0.1 |
| BWI76_RS22705 | -0.5 |
| BWI76_RS26055 | -2.2 |
Uroporphyrinogen-III C-methyltransferase:
precorrin-1 + S-adenosyl-L-methionine→precorrin-2 + S-adenosyl-L-homocysteine (EC 2.1.1.107) |
| BWI76_RS11435 | -0.1 |
| BWI76_RS22705 | -0.5 |
| BWI76_RS26055 | -2.2 |
Precorrin-2 C(20)-methyltransferase:
precorrin-2 + S-adenosyl-L-methionine→precorrin-3A + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.130) |
| BWI76_RS23035 | +0.2 |
Precorrin-3B synthase:
precorrin-3A + NADH + dioxygen + H+→precorrin-3B + NAD+ + H2O (EC 1.14.13.83) |
| No genes |
Precorrin-3B C(17)-methyltransferase:
precorrin-3B + S-adenosyl-L-methionine→precorrin-4 + S-adenosyl-L-homocysteine + 2 H+ (EC 2.1.1.131) |
| BWI76_RS23050 | -1.0 |
Precorrin-4 C(11)-methyltransferase:
precorrin-4 + S-adenosyl-L-methionine→precorrin-5 + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.133) |
| BWI76_RS23060 | -0.2 |
Precorrin-6A synthase (deacetylating):
precorrin-5 + S-adenosyl-L-methionine + H2O→precorrin-6A + acetate + S-adenosyl-L-homocysteine + 2 H+ (EC 2.1.1.152) |
| No genes |
Precorrin-6A reductase (in reverse):
precorrin-6A + NADPH + H+→precorrin-6B + NADP+ (EC 1.3.1.54) |
| BWI76_RS23045 | -0.2 |
Precorrin-6Y C(5,15)-methyltransferase (decarboxylating):
precorrin-6B + H+ + S-adenosyl-L-methionine→precorrin-7 + S-adenosyl-L-homocysteine + CO2 (EC 2.1.1.132) |
| BWI76_RS23065 | +0.5 |
| BWI76_RS23070 | -1.5 |
Precorrin-6Y C(5,15)-methyltransferase (decarboxylating):
precorrin-7 + S-adenosyl-L-methionine→precorrin-8x + S-adenosyl-L-homocysteine + 2 H+ (EC 2.1.1.132) |
| BWI76_RS23065 | +0.5 |
| BWI76_RS23070 | -1.5 |
| precorrin-8x + H+→hydrogenobyrinate (EC 5.4.99.61) |
| BWI76_RS23080 | -0.5 |
Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing):
hydrogenobyrinate + 2 ATP + 2 L-glutamine + 2 H2O→hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 ADP + 2 H+ + 2 phosphate (EC 6.3.5.9) |
| BWI76_RS23090 | -0.6 |
Cobaltochelatase:
hydrogenobyrinate a,c-diamide + ATP + Co2+ + H2O→cob(II)yrinate a,c-diamide + ADP + 3 H+ + phosphate (EC 6.6.1.2) |
| No genes |
Cob(I)yrinic acid a,c-diamide adenosyltransferase:
cob(II)yrinate a,c-diamide + a [corrinoid adenosyltransferase]→cob(II)yrinate a,c-diamide-[corrinoid adenosyltranferase] (EC 2.5.1.17) |
| BWI76_RS08445 | -0.2 |
| BWI76_RS11900 | +0.7 |
| BWI76_RS20810 | +1.8 |
| BWI76_RS23165 | +0.1 |
Cob(I)yrinic acid a,c-diamide adenosyltransferase:
2 cob(II)yrinate a,c-diamide-[corrinoid adenosyltranferase] + a [reduced flavoprotein]→2 cob(I)yrinate a,c-diamide-[corrinoid adenosyltranferase] + an [oxidized flavoprotein] + 2 H+ (spontaneous) (EC 2.5.1.17) |
| BWI76_RS08445 | -0.2 |
| BWI76_RS11900 | +0.7 |
| BWI76_RS20810 | +1.8 |
| BWI76_RS23165 | +0.1 |
Cob(I)yrinic acid a,c-diamide adenosyltransferase:
2 cob(I)yrinate a,c-diamide-[corrinoid adenosyltranferase] + 2 ATP + 2 H+→2 adenosyl-cob(III)yrinate a,c-diamide + 2 a [corrinoid adenosyltransferase] + 2 triphosphate (EC 2.5.1.17) |
| BWI76_RS08445 | -0.2 |
| BWI76_RS11900 | +0.7 |
| BWI76_RS20810 | +1.8 |
| BWI76_RS23165 | +0.1 |
Adenosylcobyric acid synthase (glutamine-hydrolyzing):
adenosyl-cob(III)yrinate a,c-diamide + 4 ATP + 4 L-glutamine + 4 H2O→adenosylcobyrate + 4 L-glutamate + 4 ADP + 4 H+ + 4 phosphate (EC 6.3.5.10) |
| BWI76_RS23010 | -0.4 |
Adenosylcobinamide-phosphate synthase:
adenosylcobyrate + (R)-1-amino-2-propanol O-2-phosphate + ATP→adenosyl-cobinamide phosphate + ADP + H+ + phosphate (EC 6.3.1.10) |
| BWI76_RS23085 | +0.1 |
Adenosylcobinamide-phosphate guanylyltransferase:
adenosyl-cobinamide phosphate + GTP + H+→adenosylcobinamide-GDP + diphosphate (EC 2.7.7.62) |
| BWI76_RS18755 | +0.4 |
| BWI76_RS23005 | +1.3 |
Adenosylcobinamide-GDP ribazoletransferase:
adenosylcobinamide-GDP + α-ribazole 5'-phosphate→adenosylcobalamin 5'-phosphate + GMP + H+ (EC 2.7.8.26) |
| BWI76_RS18750 | N.D. |
Alpha-ribazole phosphatase:
adenosylcobalamin 5'-phosphate + H2O→adenosylcobalamin + phosphate (EC 3.1.3.73) |
| BWI76_RS08055 | N.D. |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information