MetaCyc Pathway: adipate degradation in Pseudomonas stutzeri RCH2

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Reactions and Genes L-Valine (N)
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Succinate--CoA ligase (ADP-forming):
adipate + ATP + coenzyme A→adipoyl-CoA + ADP + phosphate (EC 6.2.1.5)
Psest_2490 -0.2
Psest_2491 -0.4
adipoyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E)-5-carboxy-2-pentenoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.7)
Psest_3968 -0.1
Psest_0417 +0.1
Psest_0419 -0.1
Psest_0539 +0.0
Enoyl-CoA hydratase (in reverse):
(2E)-5-carboxy-2-pentenoyl-CoA + H2O→(3S)-hydroxyadipyl-CoA (EC 4.2.1.17)
Psest_2076 +0.1
Psest_2437 -1.9
Psest_2439 -1.0
Psest_2654 N.D.
Psest_2720 +0.4
Psest_3109 +0.0
Psest_3110 -0.3
Psest_3800 -0.1
Psest_3969 +0.1
Psest_4235 +0.0
3-hydroxyacyl-CoA dehydrogenase:
(3S)-hydroxyadipyl-CoA + NAD+→3-oxoadipoyl-CoA + NADH + H+ (EC 1.1.1.35)
Psest_2654 N.D.
Psest_3109 +0.0
Psest_3800 -0.1
Psest_3969 +0.1
Psest_4235 +0.0
3-oxoadipyl-CoA thiolase (in reverse):
3-oxoadipoyl-CoA + coenzyme A→succinyl-CoA + acetyl-CoA (EC 2.3.1.174)
Psest_3070 -0.6

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information