MetaCyc Pathway: noradrenaline and adrenaline degradation in Pseudomonas stutzeri RCH2

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Reactions and Genes Putrescine (N)
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Catechol O-methyltransferase:
(R)-noradrenaline + S-adenosyl-L-methionine→L-normetanephrine + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.6)
No genes
Monoamine oxidase:
(R)-noradrenaline + dioxygen + H2O→3,4-dihydroxyphenylglycolaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.4)
No genes
Phenylethanolamine N-methyltransferase:
(R)-noradrenaline + S-adenosyl-L-methionine→(R)-adrenaline + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.28)
No genes
Monoamine oxidase:
(R)-adrenaline + dioxygen + H2O→3,4-dihydroxyphenylglycolaldehyde + hydrogen peroxide + methylamine (EC 1.4.3.4)
No genes
Catechol O-methyltransferase:
(R)-adrenaline + S-adenosyl-L-methionine→metanephrine + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.6)
No genes
Monoamine oxidase:
L-normetanephrine + dioxygen + H2O→3-methoxy-4-hydroxyphenylglycolaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.4)
No genes
Alcohol dehydrogenase (in reverse):
3,4-dihydroxyphenylglycolaldehyde + NADH + H+→(R)-3,4-dihydroxyphenylglycol + NAD+ (EC 1.1.1.1)
Psest_1276 +0.1
Psest_1434 +0.0
Psest_2086 -0.0
Psest_2268 -0.0
Psest_2816 -0.2
Psest_3782 -0.1
Psest_3967 +0.3
Psest_4317 -0.1
Psest_0672 +0.3
Psest_0890 +0.4
Psest_0931 -0.2
Aldehyde dehydrogenase (NAD(+)):
3,4-dihydroxyphenylglycolaldehyde + NAD+ + H2O→3,4-dihydroxymandelate + NADH + 2 H+ (EC 1.2.1.3)
Psest_2276 +0.1
Psest_0247 +0.0
Psest_0375 -0.2
Psest_4305 -3.4
Psest_0671 +0.1
Psest_0905 +0.1
Monoamine oxidase:
metanephrine + dioxygen + H2O→3-methoxy-4-hydroxyphenylglycolaldehyde + hydrogen peroxide + methylamine (EC 1.4.3.4)
No genes
Catechol O-methyltransferase:
(R)-3,4-dihydroxyphenylglycol + S-adenosyl-L-methionine→3-methoxy-4-hydroxyphenylglycol + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.6)
No genes
Catechol O-methyltransferase:
3,4-dihydroxymandelate + S-adenosyl-L-methionine→vanillylmandelate + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.6)
No genes
Alcohol dehydrogenase:
3-methoxy-4-hydroxyphenylglycol + NAD+→3-methoxy-4-hydroxyphenylglycolaldehyde + NADH + H+ (EC 1.1.1.1)
Psest_1276 +0.1
Psest_1434 +0.0
Psest_2086 -0.0
Psest_2268 -0.0
Psest_2816 -0.2
Psest_3782 -0.1
Psest_3967 +0.3
Psest_4317 -0.1
Psest_0672 +0.3
Psest_0890 +0.4
Psest_0931 -0.2
Aldehyde dehydrogenase (NAD(+)):
3-methoxy-4-hydroxyphenylglycolaldehyde + NAD+ + H2O→vanillylmandelate + NADH + 2 H+ (EC 1.2.1.3)
Psest_2276 +0.1
Psest_0247 +0.0
Psest_0375 -0.2
Psest_4305 -3.4
Psest_0671 +0.1
Psest_0905 +0.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information