MetaCyc Pathway: adipate biosynthesis in Pseudomonas fluorescens SBW25-INTG

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Reactions and Genes malate (C) and Ammonium chloride (N); with MOPS
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3-oxoadipyl-CoA thiolase:
acetyl-CoA + succinyl-CoA→3-oxoadipoyl-CoA + coenzyme A (EC 2.3.1.174)
PFLU_RS06735 +0.0
3-hydroxyacyl-CoA dehydrogenase (in reverse):
3-oxoadipoyl-CoA + NADH + H+→(3S)-hydroxyadipyl-CoA + NAD+ (EC 1.1.1.35)
PFLU_RS07650 -0.2
PFLU_RS11090 +0.0
PFLU_RS22840 -0.0
Enoyl-CoA hydratase:
(3S)-hydroxyadipyl-CoA→(2E)-5-carboxy-2-pentenoyl-CoA + H2O (EC 4.2.1.17)
PFLU_RS07105 +0.1
PFLU_RS07650 -0.2
PFLU_RS08485 -1.0
PFLU_RS10835 -0.3
PFLU_RS12025 -1.4
PFLU_RS13550 -0.0
PFLU_RS14775 +0.2
PFLU_RS14785 -0.0
PFLU_RS16080 -0.0
PFLU_RS22820 -0.1
PFLU_RS22840 -0.0
PFLU_RS24260 -0.0
(2E)-5-carboxy-2-pentenoyl-CoA + FADH2→adipoyl-CoA + FAD + H+
No genes
Succinate--CoA ligase (ADP-forming) (in reverse):
adipoyl-CoA + ADP + phosphate→adipate + ATP + coenzyme A (EC 6.2.1.5)
PFLU_RS08970 N.D.
PFLU_RS08975 N.D.

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information