MetaCyc Pathway: 2-methylcitrate cycle II in Pseudomonas stutzeri RCH2

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Reactions and Genes L-tyrosine (C)
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Propionate--CoA ligase:
propanoate + ATP + coenzyme A→propanoyl-CoA + AMP + diphosphate (EC 6.2.1.17)
Psest_2657 +0.0
2-methylcitrate synthase:
propanoyl-CoA + oxaloacetate + H2O→(2S,3S)-2-methylcitrate + coenzyme A + H+ (EC 2.3.3.5)
Psest_2320 -0.0
(2S,3S)-2-methylcitrate→2-methyl-trans-aconitate + H2O (EC 4.2.1.117)
Psest_2319 N.D.
2-methyl-trans-aconitate→cis-2-methylaconitate
No genes
2-methylisocitrate dehydratase (in reverse):
cis-2-methylaconitate + H2O→(2R,3S)-2-methylisocitrate (EC 4.2.1.99)
Psest_2309 N.D.
Psest_2319 N.D.
Psest_2521 -0.3
Methylisocitrate lyase:
(2R,3S)-2-methylisocitrate→pyruvate + succinate (EC 4.1.3.30)
Psest_2321 +1.6

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information