MetaCyc Pathway: 4-hydroxy-2-nonenal detoxification in Pseudomonas stutzeri RCH2

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Reactions and Genes L-tyrosine (C)
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Glutathione transferase:
4-hydroxy-2-nonenal + glutathione→(glutathion-S-yl)-4-hydroxy-2-nonenal (EC 2.5.1.18)
Psest_1131 -0.2
Psest_1219 +0.2
Psest_1421 +1.3
Psest_1859 -0.1
Psest_1991 -0.2
Psest_2378 -0.2
Psest_2571 -0.3
Psest_3511 -4.1
Psest_0049 -0.1
Psest_0056 -0.1
Psest_0868 +0.1
(glutathion-S-yl)-4-hydroxy-2-nonenal + H2O→S-(4-hydroxy-nonenal-3-yl)-L-cysteinylglycine + L-glutamate (EC 3.4.19.13)
No genes
S-(4-hydroxy-nonenal-3-yl)-L-cysteinylglycine + H2O→S-(4-hydroxy-nonenal-3-yl)-L-cysteine + glycine (EC 3.4.13.23)
No genes
Cysteine-S-conjugate N-acetyltransferase:
S-(4-hydroxy-nonenal-3-yl)-L-cysteine + acetyl-CoA→4-hydroxy-2-nonenal-N-acetyl-L-cysteine + coenzyme A + H+ (EC 2.3.1.80)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information