MetaCyc Pathway: superpathway of glyoxylate bypass and TCA in Pseudomonas stutzeri RCH2

Reactions and Genes	L-Leucine (C)
2-oxoglutarate + coenzyme A + NAD+→succinyl-CoA + CO2 + NADH (EC 1.2.1.105)
Psest_2218	-0.1
Succinate--CoA ligase (ADP-forming) (in reverse): succinyl-CoA + ADP + phosphate→succinate + ATP + coenzyme A (EC 6.2.1.5)
Psest_2490	-0.1
Psest_2491	-0.5
Succinate dehydrogenase (ubiquinone): succinate[in] + an electron-transfer quinone→fumarate[in] + an electron-transfer quinol (EC 1.3.5.1)
Psest_2495	N.D.
Psest_2496	N.D.
Psest_2497	N.D.
Psest_2498	N.D.
Fumarate hydratase (in reverse): fumarate + H2O→(S)-malate (EC 4.2.1.2)
Psest_2682	-0.4
Psest_3193	N.D.
Malate dehydrogenase: (S)-malate + NAD+→oxaloacetate + NADH + H+ (EC 1.1.1.37; 1.1.1.38)
No genes
(S)-malate[in] + an electron-transfer quinone→oxaloacetate[in] + an electron-transfer quinol (EC 1.1.5.4)
Psest_3238	N.D.
Citrate (Si)-synthase: oxaloacetate + acetyl-CoA + H2O→citrate + coenzyme A + H+ (EC 2.3.3.1; 2.3.3.16; 2.3.3.3)
Psest_2499	N.D.
Aconitate hydratase: citrate→cis-aconitate + H2O (EC 4.2.1.3)
Psest_2309	N.D.
Psest_2319	N.D.
Psest_2521	+0.1
Aconitate hydratase: cis-aconitate + H2O→D-threo-isocitrate (EC 4.2.1.3)
Psest_2309	N.D.
Psest_2319	N.D.
Psest_2521	+0.1
Isocitrate lyase: D-threo-isocitrate→succinate + glyoxylate (EC 4.1.3.1)
Psest_2014	-5.4
Isocitrate dehydrogenase (NADP(+)): D-threo-isocitrate + NADP+→2-oxoglutarate + CO2 + NADPH (EC 1.1.1.42)
Psest_2023	+0.8
Psest_2024	+0.4
Malate synthase: acetyl-CoA + glyoxylate + H2O→(S)-malate + coenzyme A + H+ (EC 2.3.3.9)
Psest_0354	-2.1
Psest_3837	+0.1

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information