MetaCyc Pathway: adipate biosynthesis in Pseudomonas stutzeri RCH2

Add experiment(s):


Reactions and Genes L-Isoleucine (C)
remove
3-oxoadipyl-CoA thiolase:
acetyl-CoA + succinyl-CoA→3-oxoadipoyl-CoA + coenzyme A (EC 2.3.1.174)
Psest_3070 +0.3
3-hydroxyacyl-CoA dehydrogenase (in reverse):
3-oxoadipoyl-CoA + NADH + H+→(3S)-hydroxyadipyl-CoA + NAD+ (EC 1.1.1.35)
Psest_2654 N.D.
Psest_3109 +0.1
Psest_3800 -0.1
Psest_3969 +0.1
Psest_4235 +0.0
Enoyl-CoA hydratase:
(3S)-hydroxyadipyl-CoA→(2E)-5-carboxy-2-pentenoyl-CoA + H2O (EC 4.2.1.17)
Psest_2076 +0.1
Psest_2437 -2.1
Psest_2439 +0.1
Psest_2654 N.D.
Psest_2720 +0.2
Psest_3109 +0.1
Psest_3110 +0.1
Psest_3800 -0.1
Psest_3969 +0.1
Psest_4235 +0.0
(2E)-5-carboxy-2-pentenoyl-CoA + FADH2→adipoyl-CoA + FAD + H+
No genes
Succinate--CoA ligase (ADP-forming) (in reverse):
adipoyl-CoA + ADP + phosphate→adipate + ATP + coenzyme A (EC 6.2.1.5)
Psest_2490 +0.1
Psest_2491 -0.1

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information