MetaCyc Pathway: 4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis II in Pantoea sp. MT58

Reactions and Genes	Ying_Nucleobase14 rep A; time point 3
	remove
pyridoxine_[out] + H⁺_[out]→pyridoxine_[in] + H⁺_[in]
No genes
Pyridoxal kinase: pyridoxine + ATP→pyridoxine 5'-phosphate + ADP + H⁺ (EC 2.7.1.35)
IAI47_10510	+0.2
Pyridoxine 4-dehydrogenase: pyridoxine + NADP⁺→pyridoxal + NADPH + H⁺ (EC 1.1.1.65)
IAI47_18880	+0.0
Pyridoxal 5'-phosphate synthase: pyridoxine 5'-phosphate + dioxygen→pyridoxal 5'-phosphate + hydrogen peroxide (EC 1.4.3.5)
IAI47_10520	-1.5
Pyridoxal kinase: pyridoxal + ATP→pyridoxal 5'-phosphate + ADP + H⁺ (EC 2.7.1.35)
IAI47_10510	+0.2
pyridoxal 5'-phosphate + an [HMP-P synthase]-L-lysine→an [HMP-P synthase]-(PLP-imine)-L-lysine + H⁺ + H₂O
No genes
an [HMP-P synthase]-(PLP-imine)-L-lysine + 2 Fe³⁺ + [an HMP-P synthase]-L-histidine + 4 H₂O→4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 2 Fe²⁺ + 3-oxopropanoate + 2 H⁺ + an [HMP-P synthase]-3-(2-hydroxyacetyl)-L-alanine + an [HMP-P synthase]-L-lysine
No genes
Phosphomethylpyrimidine kinase: 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP→4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP (EC 2.7.4.7)
IAI47_06810	-3.0

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Pathway details at MetaCyc
Fitness data for 4 genes
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All MetaCyc pathways for Pantoea sp. MT58

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information