MetaCyc Pathway: adlupulone and adhumulone biosynthesis in Klebsiella michiganensis M5al

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Reactions and Genes 2'-Deoxycytidine 10 mM (C)
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Acetate--CoA ligase:
2-methylbutanoate + ATP + coenzyme A→(2S)-2-methylbutanoyl-CoA + AMP + diphosphate (EC 6.2.1.1)
BWI76_RS02095 -1.6
Phloroisovalerophenone synthase:
(2S)-2-methylbutanoyl-CoA + 3 malonyl-CoA + 3 H+→phlormethylbutanophenone + 3 CO2 + 4 coenzyme A (EC 2.3.1.156)
No genes
phlormethylbutanophenone + prenyl diphosphate→4-prenylphlormethylbutanophenone + diphosphate + H+ (EC 2.5.1.136)
No genes
4-prenylphlormethylbutanophenone + prenyl diphosphate→deoxyadlupulone + diphosphate (EC 2.5.1.137)
No genes
deoxyadlupulone + prenyl diphosphate→adlupulone + diphosphate (EC 2.5.1.137)
No genes
deoxyadlupulone + a reduced two electron carrier + dioxygen→adhumulone + an oxidized electron carrier + H2O (EC 1.14.99.M4)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information