MetaCyc Pathway: L-valine degradation I in Burkholderia phytofirmans PsJN

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Reactions and Genes adipate (C)
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Branched-chain-amino-acid transaminase:
L-valine + 2-oxoglutarate→3-methyl-2-oxobutanoate + L-glutamate (EC 2.6.1.42)
BPHYT_RS16285 -0.1
2-oxoisovalerate dehydrogenase (acylating):
3-methyl-2-oxobutanoate + coenzyme A + NAD+→isobutanoyl-CoA + CO2 + NADH (EC 1.2.1.25)
No genes
isobutanoyl-CoA + an oxidized electron-transfer flavoprotein + H+→methylacrylyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.5)
No genes
methylacrylyl-CoA + H2O→(S)-3-hydroxy-isobutanoyl-CoA (EC 4.2.1.150)
BPHYT_RS02345 +0.7
BPHYT_RS03225 -0.1
BPHYT_RS03235 +0.1
BPHYT_RS03825 N.D.
BPHYT_RS08375 N.D.
BPHYT_RS08630 -0.2
BPHYT_RS09560 -0.1
BPHYT_RS10815 N.D.
BPHYT_RS11780 N.D.
BPHYT_RS13545 -3.4
BPHYT_RS14830 -0.3
BPHYT_RS25360 N.D.
BPHYT_RS25695 N.D.
BPHYT_RS27105 +0.1
BPHYT_RS27895 +0.5
BPHYT_RS28020 N.D.
BPHYT_RS28620 +0.8
BPHYT_RS35465 +0.5
3-hydroxyisobutyryl-CoA hydrolase:
(S)-3-hydroxy-isobutanoyl-CoA + H2O→(S)-3-hydroxy-isobutanoate + coenzyme A + H+ (EC 3.1.2.4)
BPHYT_RS28015 -0.1
3-hydroxyisobutyrate dehydrogenase:
(S)-3-hydroxy-isobutanoate + NAD+→(S)-methylmalonate-semialdehyde + NADH + H+ (EC 1.1.1.31)
BPHYT_RS03225 -0.1
BPHYT_RS06760 +0.1
BPHYT_RS09560 -0.1
BPHYT_RS11485 +0.3
BPHYT_RS13545 -3.4
BPHYT_RS25645 -1.1
BPHYT_RS28025 -0.1
BPHYT_RS29415 N.D.
BPHYT_RS34155 +0.2
(S)-3-amino-2-methylpropionate transaminase (in reverse):
(S)-methylmalonate-semialdehyde + L-glutamate→(S)-3-amino-2-methylpropanoate + 2-oxoglutarate (EC 2.6.1.22)
No genes
Methylmalonate-semialdehyde dehydrogenase (acylating):
(S)-methylmalonate-semialdehyde + coenzyme A + NAD+ + H2O→propanoyl-CoA + hydrogen carbonate + NADH + H+ (EC 1.2.1.27)
BPHYT_RS19500 +0.2
BPHYT_RS21100 N.D.
BPHYT_RS28030 +1.0
BPHYT_RS28150 -0.2
BPHYT_RS28825 +0.3

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information