MetaCyc Pathway: valproate β-oxidation in Pseudomonas fluorescens SBW25-INTG

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Reactions and Genes p-Coumaric (C) and Ammonium chloride (N); with TAPS
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Butyrate--CoA ligase:
valproate + ATP + coenzyme A→valproyl-CoA + AMP + diphosphate (EC 6.2.1.2)
No genes
valproyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E)-2-propylpent-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.5)
No genes
Enoyl-CoA hydratase (in reverse):
(2E)-2-propylpent-2-enoyl-CoA + H2O→(3S)-3-hydroxy-2-propylpentanoyl-CoA (EC 4.2.1.17)
PFLU_RS07105 -0.4
PFLU_RS07650 -1.0
PFLU_RS08485 -0.2
PFLU_RS10835 -0.8
PFLU_RS12025 -4.2
PFLU_RS13550 -0.3
PFLU_RS14775 -0.5
PFLU_RS14785 -0.1
PFLU_RS16080 -5.6
PFLU_RS22820 +0.4
PFLU_RS22840 +0.1
PFLU_RS24260 -0.3
3-hydroxyacyl-CoA dehydrogenase:
(3S)-3-hydroxy-2-propylpentanoyl-CoA + NAD+→3-oxo-2-propylpentanoyl-CoA + NADH + H+ (EC 1.1.1.35)
PFLU_RS07650 -1.0
PFLU_RS11090 -0.1
PFLU_RS22840 +0.1
Acetyl-CoA C-acyltransferase (in reverse):
3-oxo-2-propylpentanoyl-CoA + coenzyme A→pentanoyl-CoA + propanoyl-CoA (EC 2.3.1.16)
PFLU_RS03225 -0.9
PFLU_RS06735 -5.4
PFLU_RS07655 -1.1
PFLU_RS10575 +0.2
PFLU_RS14765 +0.1
PFLU_RS16065 +0.3
PFLU_RS17190 -0.4
PFLU_RS21180 -0.3
PFLU_RS22845 +0.2
pentanoyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E)-pent-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.1)
PFLU_RS02225 +0.6
(2E)-pent-2-enoyl-CoA + H2O→(3S)-3-hydroxypentanoyl-CoA
No genes
3-hydroxyacyl-CoA dehydrogenase:
(3S)-3-hydroxypentanoyl-CoA + NAD+→3-oxopentanoyl-CoA + NADH + H+ (EC 1.1.1.35)
PFLU_RS07650 -1.0
PFLU_RS11090 -0.1
PFLU_RS22840 +0.1
Acetyl-CoA C-acyltransferase (in reverse):
3-oxopentanoyl-CoA + coenzyme A→propanoyl-CoA + acetyl-CoA (EC 2.3.1.16; 2.3.1.9)
PFLU_RS03225 -0.9
PFLU_RS06735 -5.4
PFLU_RS07655 -1.1
PFLU_RS10575 +0.2
PFLU_RS14765 +0.1
PFLU_RS16065 +0.3
PFLU_RS17190 -0.4
PFLU_RS21180 -0.3
PFLU_RS22845 +0.2

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information