| Reactions and Genes | Azelaic (C) |
|---|
| remove |
| a 2,3,4-saturated fatty acid + ATP + coenzyme A→a 2,3,4-saturated fatty acyl CoA + AMP + diphosphate |
| No genes |
Acyl-CoA oxidase:
a 2,3,4-saturated fatty acyl CoA + dioxygen→a (2E)-2-enoyl-CoA + hydrogen peroxide (EC 1.3.3.6) |
| No genes |
Enoyl-CoA hydratase (in reverse):
a (2E)-2-enoyl-CoA + H2O→a 2,3,4-saturated (3S)-3-hydroxyacyl-CoA (EC 4.2.1.17) |
| BPHYT_RS02345 | +0.1 |
| BPHYT_RS03225 | -0.0 |
| BPHYT_RS03235 | +0.3 |
| BPHYT_RS03825 | N.D. |
| BPHYT_RS06755 | N.D. |
| BPHYT_RS06760 | +0.5 |
| BPHYT_RS08375 | N.D. |
| BPHYT_RS08630 | -0.1 |
| BPHYT_RS09560 | -2.8 |
| BPHYT_RS10815 | N.D. |
| BPHYT_RS11780 | N.D. |
| BPHYT_RS13345 | -0.0 |
| BPHYT_RS13545 | -0.5 |
| BPHYT_RS14830 | -0.1 |
| BPHYT_RS17335 | +0.3 |
| BPHYT_RS17350 | N.D. |
| BPHYT_RS20025 | +0.4 |
| BPHYT_RS25360 | N.D. |
| BPHYT_RS25695 | N.D. |
| BPHYT_RS27105 | -0.0 |
| BPHYT_RS27895 | +0.1 |
| BPHYT_RS28015 | -0.2 |
| BPHYT_RS28020 | N.D. |
| BPHYT_RS28620 | +0.1 |
| BPHYT_RS35465 | +0.6 |
3-hydroxyacyl-CoA dehydrogenase:
a 2,3,4-saturated (3S)-3-hydroxyacyl-CoA + NAD+→a 2,3,4-saturated 3-oxoacyl-CoA + NADH + H+ (EC 1.1.1.35) |
| BPHYT_RS03225 | -0.0 |
| BPHYT_RS06760 | +0.5 |
| BPHYT_RS09560 | -2.8 |
| BPHYT_RS13545 | -0.5 |
| BPHYT_RS34155 | -0.6 |
Acetyl-CoA C-acyltransferase (in reverse):
a 2,3,4-saturated 3-oxoacyl-CoA + coenzyme A→a 2,3,4-saturated fatty acyl CoA + acetyl-CoA (EC 2.3.1.16) |
| BPHYT_RS02230 | -0.1 |
| BPHYT_RS03230 | -0.3 |
| BPHYT_RS08275 | +0.1 |
| BPHYT_RS09150 | +0.0 |
| BPHYT_RS09180 | +0.2 |
| BPHYT_RS09565 | -3.7 |
| BPHYT_RS17345 | +0.2 |
| BPHYT_RS21955 | -0.3 |
| BPHYT_RS29385 | -0.4 |
Citrate (Si)-synthase:
acetyl-CoA + oxaloacetate + H2O→citrate + coenzyme A + H+ (EC 2.3.3.1; 2.3.3.16; 2.3.3.3) |
| BPHYT_RS15810 | +0.5 |
| BPHYT_RS19980 | -0.2 |
| BPHYT_RS20940 | -0.4 |
| BPHYT_RS27440 | +0.4 |
| BPHYT_RS33920 | -1.0 |
Aconitate hydratase:
citrate→cis-aconitate + H2O (EC 4.2.1.3) |
| BPHYT_RS10160 | -0.1 |
| BPHYT_RS30145 | +0.0 |
| BPHYT_RS33980 | -0.3 |
Aconitate hydratase:
cis-aconitate + H2O→D-threo-isocitrate (EC 4.2.1.3) |
| BPHYT_RS10160 | -0.1 |
| BPHYT_RS30145 | +0.0 |
| BPHYT_RS33980 | -0.3 |
Isocitrate lyase:
D-threo-isocitrate→glyoxylate + succinate (EC 4.1.3.1) |
| BPHYT_RS12285 | -3.6 |
| BPHYT_RS25670 | +0.0 |
Malate synthase:
acetyl-CoA + glyoxylate + H2O→(S)-malate + coenzyme A + H+ (EC 2.3.3.9) |
| BPHYT_RS09815 | -1.1 |
| BPHYT_RS12305 | -0.2 |
| BPHYT_RS31665 | N.D. |
Succinate dehydrogenase (ubiquinone):
succinate[in] + an electron-transfer quinone→fumarate[in] + an electron-transfer quinol (EC 1.3.5.1) |
| BPHYT_RS33935 | N.D. |
Fumarate hydratase (in reverse):
fumarate + H2O→(S)-malate (EC 4.2.1.2) |
| BPHYT_RS06985 | -0.4 |
| BPHYT_RS14615 | -0.5 |
Malate dehydrogenase:
(S)-malate + NAD+→oxaloacetate + NADH + H+ (EC 1.1.1.37; 1.1.1.38) |
| BPHYT_RS27110 | -0.1 |
| BPHYT_RS28460 | -0.4 |
| BPHYT_RS33955 | N.D. |
Phosphoenolpyruvate carboxykinase (ATP):
oxaloacetate + ATP→phosphoenolpyruvate + ADP + CO2 (EC 4.1.1.49) |
| No genes |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information