MetaCyc Pathway: TCA cycle III (animals) in Pseudomonas stutzeri RCH2

Reactions and Genes	Paraquat dichloride 0.015 mg/ml
2-oxoglutarate + coenzyme A + NAD+→succinyl-CoA + CO2 + NADH (EC 1.2.1.105)
Psest_2218	+0.4
Succinate--CoA ligase (ADP-forming) (in reverse): succinyl-CoA + ADP + phosphate→succinate + ATP + coenzyme A (EC 6.2.1.5)
Psest_2490	+0.5
Psest_2491	+0.5
Succinate--CoA ligase (GDP-forming) (in reverse): succinyl-CoA + GDP + phosphate→succinate + coenzyme A + GTP (EC 6.2.1.4)
No genes
Succinate dehydrogenase (ubiquinone): succinate[in] + a ubiquinone→fumarate[in] + a ubiquinol (EC 1.3.5.1)
Psest_2496	N.D.
Fumarate hydratase (in reverse): fumarate + H2O→(S)-malate (EC 4.2.1.2)
Psest_2682	-2.8
Psest_3193	N.D.
Malate dehydrogenase: (S)-malate + NAD+→oxaloacetate + NADH + H+ (EC 1.1.1.37; 1.1.1.38)
No genes
Citrate (Si)-synthase: oxaloacetate + acetyl-CoA + H2O→citrate + coenzyme A + H+ (EC 2.3.3.1; 2.3.3.16; 2.3.3.3)
Psest_2499	N.D.
Aconitate hydratase: citrate→cis-aconitate + H2O (EC 4.2.1.3)
Psest_2309	N.D.
Psest_2319	N.D.
Psest_2521	-0.3
Aconitate hydratase: cis-aconitate + H2O→D-threo-isocitrate (EC 4.2.1.3)
Psest_2309	N.D.
Psest_2319	N.D.
Psest_2521	-0.3
Isocitrate--homoisocitrate dehydrogenase: D-threo-isocitrate + NAD+→2-oxoglutarate + CO2 + NADH (EC 1.1.1.286; 1.1.1.41)
No genes

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information