MetaCyc Pathway: superpathway of glyoxylate cycle and fatty acid degradation in Pseudomonas stutzeri RCH2

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Reactions and Genes Paraquat dichloride 0.015 mg/ml
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a 2,3,4-saturated fatty acid + ATP + coenzyme A→a 2,3,4-saturated fatty acyl CoA + AMP + diphosphate
No genes
Acyl-CoA oxidase:
a 2,3,4-saturated fatty acyl CoA + dioxygen→a (2E)-2-enoyl-CoA + hydrogen peroxide
(EC 1.3.3.6)
No genes
Enoyl-CoA hydratase (in reverse):
a (2E)-2-enoyl-CoA + H2O→a 2,3,4-saturated (3S)-3-hydroxyacyl-CoA
(EC 4.2.1.17)
Psest_2076 +0.0
Psest_2437 -0.4
Psest_2439 +0.6
Psest_2654 N.D.
Psest_2720 +0.0
Psest_3109 -0.0
Psest_3110 -0.1
Psest_3800 -0.6
Psest_3969 -0.2
Psest_4235 -0.1
3-hydroxyacyl-CoA dehydrogenase:
a 2,3,4-saturated (3S)-3-hydroxyacyl-CoA + NAD+→a 2,3,4-saturated 3-oxoacyl-CoA + NADH + H+
(EC 1.1.1.35)
Psest_2654 N.D.
Psest_3800 -0.6
Psest_3969 -0.2
Psest_4235 -0.1
Acetyl-CoA C-acyltransferase (in reverse):
a 2,3,4-saturated 3-oxoacyl-CoA + coenzyme A→a 2,3,4-saturated fatty acyl CoA + acetyl-CoA
(EC 2.3.1.16)
Psest_1076 +0.2
Psest_1829 -0.0
Psest_2446 +0.4
Psest_2476 +0.1
Psest_2653 N.D.
Psest_3070 +0.0
Citrate (Si)-synthase:
acetyl-CoA + oxaloacetate + H2O→citrate + coenzyme A + H+
(EC 2.3.3.1; 2.3.3.16; 2.3.3.3)
Psest_2499 N.D.
Aconitate hydratase:
citrate→cis-aconitate + H2O
(EC 4.2.1.3)
Psest_2309 N.D.
Psest_2319 N.D.
Psest_2521 -0.3
Aconitate hydratase:
cis-aconitate + H2O→D-threo-isocitrate
(EC 4.2.1.3)
Psest_2309 N.D.
Psest_2319 N.D.
Psest_2521 -0.3
Isocitrate lyase:
D-threo-isocitrate→glyoxylate + succinate
(EC 4.1.3.1)
Psest_2014 -0.1
Malate synthase:
acetyl-CoA + glyoxylate + H2O→(S)-malate + coenzyme A + H+
(EC 2.3.3.9)
Psest_0354 +0.2
Psest_3837 -0.2
Succinate dehydrogenase (ubiquinone):
succinate[in] + an electron-transfer quinone→fumarate[in] + an electron-transfer quinol
(EC 1.3.5.1)
Psest_2495 N.D.
Psest_2496 N.D.
Psest_2497 N.D.
Psest_2498 N.D.
Fumarate hydratase (in reverse):
fumarate + H2O→(S)-malate
(EC 4.2.1.2)
Psest_2682 -2.8
Psest_3193 N.D.
Malate dehydrogenase:
(S)-malate + NAD+→oxaloacetate + NADH + H+
(EC 1.1.1.37; 1.1.1.38)
No genes
Phosphoenolpyruvate carboxykinase (ATP):
oxaloacetate + ATP→phosphoenolpyruvate + ADP + CO2
(EC 4.1.1.49)
Psest_3988 +1.6

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information