MetaCyc Pathway: superpathway of L-threonine biosynthesis in Pseudomonas stutzeri RCH2

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Reactions and Genes Phosphomycin 0.012 mg/ml
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Aspartate transaminase (in reverse):
oxaloacetate + L-glutamate→L-aspartate + 2-oxoglutarate (EC 2.6.1.1)
Psest_1268 -0.0
Psest_1570 +0.3
Psest_1710 +1.1
Psest_1990 +0.3
Psest_0779 +0.4
Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP (EC 2.7.2.4)
Psest_2988 +0.7
Psest_4094 -0.0
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate (EC 1.2.1.11)
Psest_1328 N.D.
Psest_2587 +0.3
Psest_2588 N.D.
Homoserine dehydrogenase (in reverse):
L-aspartate 4-semialdehyde + NAD(P)H + H+→L-homoserine + NAD(P)+ (EC 1.1.1.3)
Psest_2136 +0.6
Psest_3126 N.D.
Homoserine kinase:
L-homoserine + ATP→O-phospho-L-homoserine + ADP + H+ (EC 2.7.1.39)
Psest_2327 +0.3
Psest_4221 +0.0
Threonine synthase:
O-phospho-L-homoserine + H2O→L-threonine + phosphate (EC 4.2.3.1)
Psest_3125 N.D.

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information