MetaCyc Pathway: superpathway of L-methionine biosynthesis (transsulfuration) in Enterobacter sp. TBS_079

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Reactions and Genes Putrescine (N)
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Aspartate transaminase (in reverse):
oxaloacetate + L-glutamate→L-aspartate + 2-oxoglutarate (EC 2.6.1.1)
MPMX20_00609 +0.0
MPMX20_00612 +0.1
MPMX20_01049 -0.1
MPMX20_01059 +0.1
MPMX20_01157 -0.0
MPMX20_01586 -0.9
MPMX20_02048 -0.1
MPMX20_02230 -0.1
MPMX20_02425 -0.2
MPMX20_03220 -1.0
MPMX20_04048 +0.0
Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP (EC 2.7.2.4)
MPMX20_00240 -0.1
MPMX20_00710 -4.4
MPMX20_04530 +0.1
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate (EC 1.2.1.11)
MPMX20_02127 -0.0
MPMX20_03254 +0.6
MPMX20_04315 N.D.
Homoserine dehydrogenase (in reverse):
L-aspartate 4-semialdehyde + NAD(P)H + H+→L-homoserine + NAD(P)+ (EC 1.1.1.3)
MPMX20_00710 -4.4
MPMX20_04530 +0.1
Homoserine O-succinyltransferase:
L-homoserine + succinyl-CoA→O-succinyl-L-homoserine + coenzyme A (EC 2.3.1.46)
MPMX20_00230 -3.4
Cystathionine gamma-synthase:
O-succinyl-L-homoserine + L-cysteine→L-cystathionine + H+ + succinate (EC 2.5.1.48)
MPMX20_04531 -2.3
Cysteine-S-conjugate beta-lyase:
L-cystathionine + H2O→L-homocysteine + ammonium + pyruvate (EC 4.4.1.13)
MPMX20_02016 -0.1
MPMX20_03852 -2.8
5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase:
L-homocysteine + 5-methyltetrahydropteroyl tri-L-glutamate→L-methionine + tetrahydropteroyl tri-L-glutamate (EC 2.1.1.14)
MPMX20_02184 +0.0
MPMX20_02249 +0.4
MPMX20_04451 +0.1
Methionine synthase:
L-homocysteine + a 5-methyltetrahydrofolate→L-methionine + a tetrahydrofolate (EC 2.1.1.13)
MPMX20_00235 -0.3

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information